Preparation Some of Hydroxamic Acid Derivatives from Honey Wax Compounds and Study the Biological Activity on Cancerous Tumors
Saddaa Abed Abedullah Jamal, bilal Jaser, Walled Farg Hmadi, Omar Al Obaidi.
In this paper, a number of hydroxamic acid derivatives were prepared from one of the esteric compounds found in beeswax. Palmito Hydroxamic acid was prepared by the reaction of beeswax with hydroxyl amine hydrochloride, using sodium hydroxide as the base medium (pH= 13) with heat escalation at a temperature of (80°C), for two hours. From this compound, the two compounds (N-acetoxy- Palmetto Hydroxamic acid) and (N-acetyl-N- acetoxy- Palmito Hydroxamic acid) were prepared by the of reaction (Palmito Hydroxamic acid) with acetyl chloride in certain molar ratios. The synthesized compounds were purified and their melting points were determined. Also, the characterized of these compounds were diagnosed by using (UV.VIS) infrared spectroscopy (FT.IR), and (H-NMR). The biological efficacy of these derivatives as anti-cancer was studied by using one type of cancer cell line for human carcinogenic muscle tissue. By analyzing the results obtained statistically, these compounds were found to have a significant effect on the growth of these cells. Some of these compounds have inhibition effects on the growth of metamorphic cells. The biological antibacterial activity of these synthesized compounds was studied, using two gram - negative and gram - positive pathogenic bacteria. The synthesized compounds exhibited different inhibition capacities, different diameters, depending on the type and concentration of the compound used, as well as the type of bacteria used for the study.