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Prevalence of Toxic Shock Syndrome Toxin-1 (TSST-1) Produced by Staphylococcus aureus Isolated from Patient Combined Psoriasis with Urinary Tract Infections (UTIs) and Gastroenteritis in Age Groups Between 8-18 Years

Abstract

Ala'a Abdlhussein Abdulzahra, Rabehshakir Al-Jameel, Mohammed Abd-ZaidAkool, Dheyaa ShnanAl-Jameel.

Psoriasis lesion may be the source of transmitting the causative bacterial agents to other parts of the body like urinary and digestive systems. Staphylococcus aureus is one of the most common bacteria which colonize the lesions of psoriasis and TSST-1 is a super antigen complicates the infections of this bacteria. This study was aimed to investigate the psoriasis lesions as a source for UTIs and gastroenteritis in age groups 8-18 years and the properties of TSST-1 produced by isolated bacteria. In this study total of 60 psoriatic patient and 30 control have been submitted to investigation for combination UTIs or gastroenteritis and screening the patient for Staphylococcus aureus and its TSST-1 by PCR technique, furthermore the toxin extracted and purified by affinity chromatography and molecular weight had been determined and the LD50 in mice calculated and study the activity of toxin as a super antigen to induce lymphocyte and other leucocytes in rabbits. Finally the antibiotic sensitivity for isolated bacteria had been achieved by disc diffusion method. The site of psoriasis onset show the dominance for body skin by 25 (41.67 %) then to nares, scalp, and nails respectively and the more affected age groups is 16-18 years with 29 (48.33 %) out of total patients. About 19(31.66 %) and 6(10.00%) of patients combined UTIs and gastroenteritis respectively, from them about 5(8.33 %) Staphylococcus aureus had been isolated as a causative agents,from which 2(3.33 %) produce TSST-1 with molecular weight 23kDa. The LD50 for purified toxin in mice determined about 50 µg/ ml which equal to 2mg/kg and the maximum level of lymphocyte and other leucocyte activated in rabbits blood was recorded at the concentration of 100 μg/ml after 48 hours of administration about 24 × 103/μL and 9 × 103/μL respectively. Finally the isolated bacteria showed highest level of susceptibility to Ampiclox and Chloramphenicol with (80%) of isolates, while it resist to Lincomycin, Metronidazole, and Bacitracin. Psoriasis lesion is a threatening source for transmission of Staphylococcus aureus to urinary and digestive systems and causing UTIs or gastroenteritis and TSST-1 produced by S. aureus is high quality super antigen causing TSS.

How to Cite this Article
Pubmed Style

Alaa Abdlhussein Abdulzahra, Rabehshakir Al-Jameel, Mohammed Abd-ZaidAkool, Dheyaa ShnanAl-Jameel. Prevalence of Toxic Shock Syndrome Toxin-1 (TSST-1) Produced by Staphylococcus aureus Isolated from Patient Combined Psoriasis with Urinary Tract Infections (UTIs) and Gastroenteritis in Age Groups Between 8-18 Years. SRP. 2020; 11(5): 80-85. doi:10.31838/srp.2020.5.14

Web Style

Alaa Abdlhussein Abdulzahra, Rabehshakir Al-Jameel, Mohammed Abd-ZaidAkool, Dheyaa ShnanAl-Jameel. Prevalence of Toxic Shock Syndrome Toxin-1 (TSST-1) Produced by Staphylococcus aureus Isolated from Patient Combined Psoriasis with Urinary Tract Infections (UTIs) and Gastroenteritis in Age Groups Between 8-18 Years. http://www.sysrevpharm.org/?mno=106841 [Access: March 29, 2021]. doi:10.31838/srp.2020.5.14

AMA (American Medical Association) Style

Alaa Abdlhussein Abdulzahra, Rabehshakir Al-Jameel, Mohammed Abd-ZaidAkool, Dheyaa ShnanAl-Jameel. Prevalence of Toxic Shock Syndrome Toxin-1 (TSST-1) Produced by Staphylococcus aureus Isolated from Patient Combined Psoriasis with Urinary Tract Infections (UTIs) and Gastroenteritis in Age Groups Between 8-18 Years. SRP. 2020; 11(5): 80-85. doi:10.31838/srp.2020.5.14


Vancouver/ICMJE Style

Alaa Abdlhussein Abdulzahra, Rabehshakir Al-Jameel, Mohammed Abd-ZaidAkool, Dheyaa ShnanAl-Jameel. Prevalence of Toxic Shock Syndrome Toxin-1 (TSST-1) Produced by Staphylococcus aureus Isolated from Patient Combined Psoriasis with Urinary Tract Infections (UTIs) and Gastroenteritis in Age Groups Between 8-18 Years. SRP. (2020), [cited March 29, 2021]; 11(5): 80-85. doi:10.31838/srp.2020.5.14


Harvard Style

Alaa Abdlhussein Abdulzahra, Rabehshakir Al-Jameel, Mohammed Abd-ZaidAkool, Dheyaa ShnanAl-Jameel (2020) Prevalence of Toxic Shock Syndrome Toxin-1 (TSST-1) Produced by Staphylococcus aureus Isolated from Patient Combined Psoriasis with Urinary Tract Infections (UTIs) and Gastroenteritis in Age Groups Between 8-18 Years. SRP, 11 (5), 80-85. doi:10.31838/srp.2020.5.14


Turabian Style

Alaa Abdlhussein Abdulzahra, Rabehshakir Al-Jameel, Mohammed Abd-ZaidAkool, Dheyaa ShnanAl-Jameel. 2020. Prevalence of Toxic Shock Syndrome Toxin-1 (TSST-1) Produced by Staphylococcus aureus Isolated from Patient Combined Psoriasis with Urinary Tract Infections (UTIs) and Gastroenteritis in Age Groups Between 8-18 Years. Systematic Reviews in Pharmacy, 11 (5), 80-85. doi:10.31838/srp.2020.5.14


Chicago Style

Alaa Abdlhussein Abdulzahra, Rabehshakir Al-Jameel, Mohammed Abd-ZaidAkool, Dheyaa ShnanAl-Jameel. "Prevalence of Toxic Shock Syndrome Toxin-1 (TSST-1) Produced by Staphylococcus aureus Isolated from Patient Combined Psoriasis with Urinary Tract Infections (UTIs) and Gastroenteritis in Age Groups Between 8-18 Years." Systematic Reviews in Pharmacy 11 (2020), 80-85. doi:10.31838/srp.2020.5.14


MLA (The Modern Language Association) Style

Alaa Abdlhussein Abdulzahra, Rabehshakir Al-Jameel, Mohammed Abd-ZaidAkool, Dheyaa ShnanAl-Jameel. "Prevalence of Toxic Shock Syndrome Toxin-1 (TSST-1) Produced by Staphylococcus aureus Isolated from Patient Combined Psoriasis with Urinary Tract Infections (UTIs) and Gastroenteritis in Age Groups Between 8-18 Years." Systematic Reviews in Pharmacy 11.5 (2020), 80-85. Print. doi:10.31838/srp.2020.5.14


APA (American Psychological Association) Style

Alaa Abdlhussein Abdulzahra, Rabehshakir Al-Jameel, Mohammed Abd-ZaidAkool, Dheyaa ShnanAl-Jameel (2020) Prevalence of Toxic Shock Syndrome Toxin-1 (TSST-1) Produced by Staphylococcus aureus Isolated from Patient Combined Psoriasis with Urinary Tract Infections (UTIs) and Gastroenteritis in Age Groups Between 8-18 Years. Systematic Reviews in Pharmacy, 11 (5), 80-85. doi:10.31838/srp.2020.5.14

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