Prognostic Implications of Sokal, Hasford, and EUTOS scores on Complete Hematologic and Early Molecular Responses in Newly Diagnosed Chronic Myeloid Leukemia Patients: A Prospective Cohort Study

Abstract

Indra Wijaya, Fachreza Aryo Damara, Rully M. A. Roesli, Lelani Reniarti Marsaman, Muhammad Hasan Bashari

Sokal, Hasford, and EUTOS prognostic scoring systems are widely used for chronic myeloid leukemia (CML) patients. However, whether one of these scoring systems was better predicting therapeutic responses among patients treated with tyrosine kinase inhibitor (TKI) remains elusive. This study was aimed to assess the correlation of each prognostic score with therapeutic responses—complete hematologic response (CHR) and early molecular response (EMR) after treated with Imatinib mesylate. 40 CML patients with the mean of age of 40 ± 11 years from Indonesian population were followed-up prospectively. The CHR at 3 months was seen in 40.7%, 18.6%, and 40.7% in Sokal low-, intermediate- and high-risk groups respectively, 26.0%, 40.7%, and 33.3% in Hasford low-, intermediate- and high-risk groups respectively, 100% and 0% EUTOS low- and high-risk groups respectively. The EMR at 3 months was seen in 41.7%, 16.6%, and 41.7% in Sokal low-, intermediate- and high-risk groups respectively, 29.2%, 37.5% and 33.3% in Hasford low-, intermediate- and high-risk groups respectively, 100% and 0% in EUTOS low- and high-risk groups respectively. However, none of these scoring systems predicted CHR and EMR at 3 months among CML patients treated with Imatinib.

How to Cite this Article
Pubmed Style

Wijaya I, Damara FA, Roesli RMA, Marsaman LR, Bashari MH. Prognostic Implications of Sokal, Hasford, and EUTOS scores on Complete Hematologic and Early Molecular Responses in Newly Diagnosed Chronic Myeloid Leukemia Patients: A Prospective Cohort Study. SRP. 2021; 12(1): 987-992.
doi:10.31838/srp.2021.1.138

Web Style

Wijaya I, Damara FA, Roesli RMA, Marsaman LR, Bashari MH. Prognostic Implications of Sokal, Hasford, and EUTOS scores on Complete Hematologic and Early Molecular Responses in Newly Diagnosed Chronic Myeloid Leukemia Patients: A Prospective Cohort Study. http://www.sysrevpharm.org/?mno=45815 [Access: March 29, 2021]. doi:10.31838/srp.2021.1.138

AMA (American Medical Association) Style

Wijaya I, Damara FA, Roesli RMA, Marsaman LR, Bashari MH. Prognostic Implications of Sokal, Hasford, and EUTOS scores on Complete Hematologic and Early Molecular Responses in Newly Diagnosed Chronic Myeloid Leukemia Patients: A Prospective Cohort Study. SRP. 2021; 12(1): 987-992. doi:10.31838/srp.2021.1.138



Vancouver/ICMJE Style

Wijaya I, Damara FA, Roesli RMA, Marsaman LR, Bashari MH. Prognostic Implications of Sokal, Hasford, and EUTOS scores on Complete Hematologic and Early Molecular Responses in Newly Diagnosed Chronic Myeloid Leukemia Patients: A Prospective Cohort Study. SRP. (2021), [cited March 29, 2021]; 12(1): 987-992. doi:10.31838/srp.2021.1.138



Harvard Style

Wijaya, I., Damara, . F. A., Roesli, . R. M. A., Marsaman, . L. R. & Bashari, . M. H. (2021) Prognostic Implications of Sokal, Hasford, and EUTOS scores on Complete Hematologic and Early Molecular Responses in Newly Diagnosed Chronic Myeloid Leukemia Patients: A Prospective Cohort Study. SRP, 12 (1), 987-992. doi:10.31838/srp.2021.1.138



Turabian Style

Wijaya, Indra, Fachreza Aryo Damara, Rully M. A. Roesli, Lelani Reniarti Marsaman, and Muhammad Hasan Bashari. 2021. Prognostic Implications of Sokal, Hasford, and EUTOS scores on Complete Hematologic and Early Molecular Responses in Newly Diagnosed Chronic Myeloid Leukemia Patients: A Prospective Cohort Study. Systematic Reviews in Pharmacy, 12 (1), 987-992. doi:10.31838/srp.2021.1.138



Chicago Style

Wijaya, Indra, Fachreza Aryo Damara, Rully M. A. Roesli, Lelani Reniarti Marsaman, and Muhammad Hasan Bashari. "Prognostic Implications of Sokal, Hasford, and EUTOS scores on Complete Hematologic and Early Molecular Responses in Newly Diagnosed Chronic Myeloid Leukemia Patients: A Prospective Cohort Study." Systematic Reviews in Pharmacy 12 (2021), 987-992. doi:10.31838/srp.2021.1.138



MLA (The Modern Language Association) Style

Wijaya, Indra, Fachreza Aryo Damara, Rully M. A. Roesli, Lelani Reniarti Marsaman, and Muhammad Hasan Bashari. "Prognostic Implications of Sokal, Hasford, and EUTOS scores on Complete Hematologic and Early Molecular Responses in Newly Diagnosed Chronic Myeloid Leukemia Patients: A Prospective Cohort Study." Systematic Reviews in Pharmacy 12.1 (2021), 987-992. Print. doi:10.31838/srp.2021.1.138



APA (American Psychological Association) Style

Wijaya, I., Damara, . F. A., Roesli, . R. M. A., Marsaman, . L. R. & Bashari, . M. H. (2021) Prognostic Implications of Sokal, Hasford, and EUTOS scores on Complete Hematologic and Early Molecular Responses in Newly Diagnosed Chronic Myeloid Leukemia Patients: A Prospective Cohort Study. Systematic Reviews in Pharmacy, 12 (1), 987-992. doi:10.31838/srp.2021.1.138

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