Proline Rich Antimicrobial Peptides-----A tool to Counter Antimicrobial Resistance

Abstract

Amjid Iqbal.

Bacterial resistant to antibiotics is a global health problem that necessitates the production of new effective therapeutics. Antimicrobial peptides (AMPs) are commonly accepted as viable alternatives to currently used antibiotics. Some AMPs have the ability to work against not only planktonic bacteria but microbial biofilms as well. Proline rich antimicrobial peptides (PR-AMPs) are a distinctive group of AMPs, isolated in various animal sources, exhibiting an exceptionally high proline content. PR-AMPs function through non-lytic mechanisms and are generally regarded as non-toxic to mammalian cells. These peptides block bacterial protein translation by binding on and inactivating the ribosome. Proline, the only cyclic proteinogenic amino acid has the ability to undergo cis-trans isomerisation. When two different pyrrolidine ring conformations (exo and endo pucker) are adopted, these rotational isomers along the peptidyl-proline bond have different stabilities. Protein structure has ability to regulate itself either by preferring unique conformations and by improving hydrophobic interactions. Pseudoprolines (ΨPro) are mimetics of proline and function as molecular hinges. These ΨPro can be used for tailoring cis / trans isomerization around the Xaa- ΨPro amide bond (Xaa can be any amino acid) and hydrophobicity modulation.

How to Cite this Article
Pubmed Style

Amjid Iqbal. Proline Rich Antimicrobial Peptides-----A tool to Counter Antimicrobial Resistance. SRP. 2021; 12(2): 24-31. 
doi:10.31838/srp.2021.2.3

Web Style

Amjid Iqbal. Proline Rich Antimicrobial Peptides-----A tool to Counter Antimicrobial Resistance. http://www.sysrevpharm.org/?mno=135423 [Access: March 29, 2021]. doi:10.31838/srp.2021.2.3

AMA (American Medical Association) Style

Amjid Iqbal. Proline Rich Antimicrobial Peptides-----A tool to Counter Antimicrobial Resistance. SRP. 2021; 12(2): 24-31. doi:10.31838/srp.2021.2.3



Vancouver/ICMJE Style

Amjid Iqbal. Proline Rich Antimicrobial Peptides-----A tool to Counter Antimicrobial Resistance. SRP. (2021), [cited March 29, 2021]; 12(2): 24-31. doi:10.31838/srp.2021.2.3



Harvard Style

Amjid Iqbal (2021) Proline Rich Antimicrobial Peptides-----A tool to Counter Antimicrobial Resistance. SRP, 12 (2), 24-31. doi:10.31838/srp.2021.2.3



Turabian Style

Amjid Iqbal. 2021. Proline Rich Antimicrobial Peptides-----A tool to Counter Antimicrobial Resistance. Systematic Reviews in Pharmacy, 12 (2), 24-31. doi:10.31838/srp.2021.2.3



Chicago Style

Amjid Iqbal. "Proline Rich Antimicrobial Peptides-----A tool to Counter Antimicrobial Resistance." Systematic Reviews in Pharmacy 12 (2021), 24-31. doi:10.31838/srp.2021.2.3



MLA (The Modern Language Association) Style

Amjid Iqbal. "Proline Rich Antimicrobial Peptides-----A tool to Counter Antimicrobial Resistance." Systematic Reviews in Pharmacy 12.2 (2021), 24-31. Print. doi:10.31838/srp.2021.2.3



APA (American Psychological Association) Style

Amjid Iqbal (2021) Proline Rich Antimicrobial Peptides-----A tool to Counter Antimicrobial Resistance. Systematic Reviews in Pharmacy, 12 (2), 24-31. doi:10.31838/srp.2021.2.3

Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran SRP. 2020; 11(1): 14-22 » doi: 10.5530/srp.2019.1.3
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova SRP. 2019; 10(1): 112-117 » doi: 10.5530/srp.2019.1.19
Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review Karle Pravin P, Dhawale Shashikant C SRP. 2019; 10(1): 11-14 » doi: 0.5530/srp.2019.1.2
  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar SRP. 2019; 10(1): 20-25 » doi: 10.5530/srp.2019.1.4
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi SRP. 2019; 10(1): 15-19 » doi: 10.5530/srp.2019.1.3