Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases
Abstract
Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ
Delivery systems with a pulsatile release pattern are receiving a sprouting attraction for the development of drugs for which conventional controlled-release systems with a continuous release are not ideal. Most physiological, biochemical, and molecular processes in healthy organisms display robust, predictable changes on a 24-h schedule. Chronotherapeutic products can synchronize drug delivery with circadian rhythms in order to optimize efficacy and/or minimize side effects. These products follow a sigmoidal release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Various capsular, osmotic, single and multiple unit systems are based on the use of soluble/erodible polymer coatings, rupturable membranes, and membrane permeabilities. Marketed technologies such as PULSYS™, CODAS®, TIMERx®, and DIFFUCAPS® follow one of the above mechanisms to render a sigmoidal drug release profile. So these systems are tuned according to body’s circadian clock having a potential to improve quality of patients life undergoing conventional drug therapy.
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| Pubmed Style Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ. Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases. SRP. 2010; 1(1): 55-61. doi:10.4103/0975-8453.59513 Web Style Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ. Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases. http://www.sysrevpharm.org/?mno=302644631 [Access: March 28, 2021]. doi:10.4103/0975-8453.59513 AMA (American Medical Association) Style Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ. Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases. SRP. 2010; 1(1): 55-61. doi:10.4103/0975-8453.59513 Vancouver/ICMJE Style Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ. Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases. SRP. (2010), [cited March 28, 2021]; 1(1): 55-61. doi:10.4103/0975-8453.59513 Harvard Style Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ (2010) Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases. SRP, 1 (1), 55-61. doi:10.4103/0975-8453.59513 Turabian Style Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ. 2010. Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases. Systematic Reviews in Pharmacy, 1 (1), 55-61. doi:10.4103/0975-8453.59513 Chicago Style Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ. "Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases." Systematic Reviews in Pharmacy 1 (2010), 55-61. doi:10.4103/0975-8453.59513 MLA (The Modern Language Association) Style Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ. "Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases." Systematic Reviews in Pharmacy 1.1 (2010), 55-61. Print. doi:10.4103/0975-8453.59513 APA (American Psychological Association) Style Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ (2010) Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases. Systematic Reviews in Pharmacy, 1 (1), 55-61. doi:10.4103/0975-8453.59513< |
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