Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases

Abstract

Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ

Delivery systems with a pulsatile release pattern are receiving a sprouting attraction for the development of drugs for which conventional controlled-release systems with a continuous release are not ideal. Most physiological, biochemical, and molecular processes in healthy organisms display robust, predictable changes on a 24-h schedule. Chronotherapeutic products can synchronize drug delivery with circadian rhythms in order to optimize efficacy and/or minimize side effects. These products follow a sigmoidal release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Various capsular, osmotic, single and multiple unit systems are based on the use of soluble/erodible polymer coatings, rupturable membranes, and membrane permeabilities. Marketed technologies such as PULSYS™, CODAS®, TIMERx®, and DIFFUCAPS® follow one of the above mechanisms to render a sigmoidal drug release profile. So these systems are tuned according to body’s circadian clock having a potential to improve quality of patients life undergoing conventional drug therapy.

How to Cite this Article
Pubmed Style

Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ. Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases. SRP. 2010; 1(1): 55-61.
doi:10.4103/0975-8453.59513

Web Style

Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ. Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases. http://www.sysrevpharm.org/?mno=302644631 [Access: March 28, 2021]. doi:10.4103/0975-8453.59513

AMA (American Medical Association) Style

Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ. Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases. SRP. 2010; 1(1): 55-61. doi:10.4103/0975-8453.59513



Vancouver/ICMJE Style

Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ. Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases. SRP. (2010), [cited March 28, 2021]; 1(1): 55-61. doi:10.4103/0975-8453.59513



Harvard Style

Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ (2010) Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases. SRP, 1 (1), 55-61. doi:10.4103/0975-8453.59513



Turabian Style

Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ. 2010. Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases. Systematic Reviews in Pharmacy, 1 (1), 55-61. doi:10.4103/0975-8453.59513



Chicago Style

Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ. "Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases." Systematic Reviews in Pharmacy 1 (2010), 55-61. doi:10.4103/0975-8453.59513



MLA (The Modern Language Association) Style

Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ. "Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases." Systematic Reviews in Pharmacy 1.1 (2010), 55-61. Print. doi:10.4103/0975-8453.59513



APA (American Psychological Association) Style

Shidhaye SS, Lotlikar VM, Ghule AM, Phutane PK, Kadam VJ (2010) Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases. Systematic Reviews in Pharmacy, 1 (1), 55-61. doi:10.4103/0975-8453.59513


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