Abstract

DK Satapathy37073*, Gurudutta Pattnaik37074 and S Tripathy37075

Ghrita is a clarified butter mostly used in formulations mentioned in different ayurvedic texts for its effectiveness in treatment of different dosha. It acts as excellent base in which different herbs can be incorporated for treatment of various CNS disorders. Potential protective nature of cow ghee proves to be safe for use indifferent CNS disorders including Memory loss and intellectual property. CNS protective and nootrophic action has made ghrita formulation a better choice as compared to other conventional drugs due to established Blood brain barrier penetrability, increase in the absorption and transportation of essential phytoconstituent to the target site. Due to lipid nature of cell membrane. Ghrita formulations facilitates passive diffusion of lipid soluble drugs, non-ionized nature of fat soluble drugs that helps in attaining highest concentration of drug inside cell. Psychiatric illness treatment with traditional ghrita formulation has been effective in revitalizing degenerative neuronal disorders. Herbal drugs which have enhanced lipid solubility can be administered scientifically regardless of its bimolecular characteristics in favor of its clinical importance. Clinical conditions of most nervous system disorders have been effectively managed by traditional herbs cited in ayurvedic literatures by this preparation. In this review an attempt has been done to rationalize the use of various medicated ghrita which can minimize the adverse effect and help in treatment outcome of different CNS ailments like epilepsy, mood disorders and degenerative disorders.