Regulatory-Adaptive Capabilities of the Organism after Radical Prostatectomy with Prostate Cancer of the I-II Degree

Abstract

Artyom Grigorievich Penzhoyan, Grigory Artemovich Penzhoyan, Vladimir Mikhailovich Pokrovsky, Valery Gordeevich Abushkevich

Purpose: to reveal the dynamics of regulatory and adaptive status in men after laparoscopic radical prostatectomy with a nerve-sparing result and when nerve-sparing did not result
Material and methods. Observations have been performed on 50 patients with I-II degree prostate cancer with the prostatic gland volume of more than 40 cm3 before and after radical prostatectomy. In all patients observed by the method of V.M. Pokrovsky the functional test of cardio-respiratory synchronism on the «VNS-Micro» apparatus was carried out according to the computer program "System for determining cardio-respiratory synchronism in humans". The minimum and maximum frequency limits of the gating range, the gating range, and the duration of gating development at the minimum limit of the range were determined. According to the parameters of cardio-respiratory synchronism the index of regulatory adaptive status was calculated, and regulatory adaptive capabilities were found from it. Statistical analysis of the study results was carried out using the programs: «STATISTICA 10».
Results. According to the index of regulatory adaptive status, after prostatectomy, patients were divided into individuals with good, satisfactory and low regulatory adaptive capabilities
The index of regulatory adaptive status after radical prostatectomy did not change significantly in patients with good and satisfactory regulatory adaptive capabilities. In these 33 out of 50 patients, nerve-sparing was noted as a result of radical prostatectomy performed by laparoscopic access. In patients with low regulatory adaptive capabilities, the index of regulatory adaptive status decreased by 15.3% after radical prostatectomy. This was due to an increase in the duration of the development of gating at the minimum limit of the range by 65.4%, despite the increase in the range by 40.0%. In these 17 patients, as a result of radical prostatectomy with laparoscopic access, nerve-sparing did not occur.
Conclusion. The parameters of cardio-respiratory synchronism, the index of regulatory adaptive status and regulatory adaptive capabilities reflect integratively the consequences of radical prostatectomy performed laparoscopically with a nerve-sparing result and when nerve-sparing does not result.