Research Reviews on Effect of Exercise on DAMP?s, HMGB1, Proinflammatory Cytokines and Leukocytes

Abstract

Huldani, Ilhamjaya Pattelongi, Muhammad Nasrum Massi, Irfan Idris, Agussalim Bukhari, Agung Dwi Wahyu Widodo, Harun Achmad.

Intensive exercise can induce pro and anti-inflammatory cytokines, which is clearly seen with an increase in leukocytes in the circulation.DAMPs trigger massive cytokine release including tumor necrosis factor (TNF-α), interleukin (IL) -1, IL-6, IL-8, IL-12 and IFN types I and II. HMGB1 in human monocyte culture stimulates the release of some TNF-α, IL-1, IL-6, IL-8 and inflammatory protein macrophages (MIP)-1.Exercise can cause a high inflammatory response by increasing proinflammatory and anti-inflammatory cytokines (IL6, IL8, IL10, IL1β, and TNF-α). In Men IL1β and TNF-αhigher levels than women, both at baseline values and on the results of the examination after exercise. Exercise with an exercise program can increase IFN, TNF levels-α, IL-6, IL-8, IL1β, VEGF and MCP. In aerobic exercise there were no significant changes in TNF levels-αand IL-6 but there is an increase in the number of neutrophils. Intensity and aerobic exercise in experimental animals increased TNF levels-αand IL-6 in High Intensity Interval Training (HIIT) and Moderate Intensity Training (MIT) while in short-term aerobic exercise the HMGB1 level decreased. Conclusion: Exercise can affect DAMPs, HMGB1, proinflammatory cytokines, and blood leukocytes depending on variation, duration, intensity, type of exercise, and research subjects.