Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited

Abstract

Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar

Depression is among the common psychiatric disorders, therefore the common pathways and pathogenesis associated with depression is required to be studied. In few years, role of 5-hydroxytryptamine-1A/B (5-HT1A/B) receptors in depressive disorders have been revealed. Both preclinical and clinical studies reported that the potential agonist and antagonist at 5-HT1A/B receptors have significant modulatory effects in depression. However, the collective details regarding the involvement of 5-HT1A/B receptors and the molecular pathways associated in depression is lacking. Thus, the present review evidence the link between 5-HT1A/B receptors in the brain and depression, the possible pathways involved and their alterations in depression. Further, it reviews the preclinical evidences of 5-HT1A/B receptor modulators as antidepressant agents and their effectiveness. The current review also details the clinical relevance of 5-HT1A/B receptors etiopathogenesis of major depression in humans.

How to Cite this Article
Pubmed Style

Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar. Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited. SRP. 2013; 4(1): 7-13.
doi:10.4103/0975-8453.135831

Web Style

Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar. Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited. http://www.sysrevpharm.org/?mno=302644588 [Access: March 28, 2021]. doi:10.4103/0975-8453.135831

AMA (American Medical Association) Style

Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar. Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited. SRP. 2013; 4(1): 7-13. doi:10.4103/0975-8453.135831



Vancouver/ICMJE Style

Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar. Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited. SRP. (2013), [cited March 28, 2021]; 4(1): 7-13. doi:10.4103/0975-8453.135831



Harvard Style

Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar (2013) Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited. SRP, 4 (1), 7-13. doi:10.4103/0975-8453.135831



Turabian Style

Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar. 2013. Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited. Systematic Reviews in Pharmacy, 4 (1), 7-13. doi:10.4103/0975-8453.135831



Chicago Style

Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar. "Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited." Systematic Reviews in Pharmacy 4 (2013), 7-13. doi:10.4103/0975-8453.135831



MLA (The Modern Language Association) Style

Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar. "Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited." Systematic Reviews in Pharmacy 4.1 (2013), 7-13. Print. doi:10.4103/0975-8453.135831



APA (American Psychological Association) Style

Prateek Kanade, Deepali Gupta, Mahesh Radhakrishnan, Visakh Prabhakar (2013) Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited. Systematic Reviews in Pharmacy, 4 (1), 7-13. doi:10.4103/0975-8453.135831

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