Salivary Interleukin ? 11 Levels in Multiple Teeth Implants Patients Before and After Suture Removal (Comparative Study)

Abstract

Nafhat Almisk Amer Saleh, Ammar Luay Alshibib

Introduction: Interleukin-11 (IL-11) is a cytokine with many functions as it has a significant role in the inflammatory processes of the dental tissue. Also, It has been stated to have a role in inhibiting the pro-inflammatory cytokines’ production such as IL-1β, tumor necrosis factor α, IL-6.
Objective: To investigate the levels of interleukin 11 (IL-11) are before and after removal of sutures of dental implants which are used as fixators for dental protheses.
Materials and Methods: A random comparative cross-sectional study were done on dental implant patients whose age ranges between 30-40 years old who were free from any systemic diseases and were non-smokers at Isra University Dentistry College, Baghdad, Iraq. Among 40 patients selected as the study sample, 2 samples were taken from each patient, as the study was done in 2 phases, one phase prior to and one phase after removal of sutures, 40 samples were in study (A) in which their samples were taken after implant placement immediately by taking 5 ml of each patient saliva, while the other 40 samples in study (B) of the same patients were taken after removal of the sutures, 10 days after taking the first samples. For our study, 2 to 4 Implants were used for each patient and many flap suturing techniques were used, the system implant used was of ‘ot-medical’ type which was made in Germany and Interleukin-11 bioMérieux kit used which was made in France, levels of IL-11 were assessed in the samples by immunosorbent enzyme-linked assay. SPSS version 16 was used for statistical analysis.
Results: The values of interleukin-11 were significantly higher in the samples study (A) after inserting the implants than in the samples of study (B). The concentration of Interleukin-11 were in higher in study (A) because of the aggressive inflammatory process due to insertion of the dental implants.
Discussion: The levels of Interleukin-11 are much more after inserting the implant compared to after removal of the suture due to alleviation of the inflammatory condition (P<0.003).
Conclusion: Interleukin-11 acts an anti-inflammatory cytokine, so after insertion of the implant, being a foreign body, the IL-11 highly increases compared to reduction of the inflammatory process by removal of the sutures.