Solid Lipid Nanoparticles Delivery Systems for Colon Cancer Chemotherapy: A Critical Review

Abstract

Basma Y. Al-Najjar, Saad A. Hussain.

Therapeutic approaches for targeting colon cancers are currently of significant importance important because of possible remission, reduction of cancer metastases, and increased success pf surgery or radiotherapy. Colonic drug delivery is becoming the increasingly preferred route for drug administration; however, it has many limitations that can be avoided by the use of proper carrier systems. Currently, many solid lipid nanoparticle systems (SLNs) were developed to enable the formulation of hydrophobic and poorly water-soluble drugs including those utilized as colonic drug delivery systems. They have many advantages including high bioavailability, high biocompatibility, cost-effectiveness, controlled release, physical stability, and safety, besides, avoidance of using organic solvents and capability of large-scale production and sterilization. Various studies provide important insights into the use of SLN delivery system to treat colon cancer. However, there is a general lack of data from clinical trials and further studies are recommended to evaluate SLNs in animal models.