Solid Lipid Nanoparticles (SLN) as a Novel Drug Delivery System: A Theoretical Review

Abstract

Ahmed A.A Alsaad, Ahmed A. Hussien, Mowafaq M. Gareeb

The introduction of solid Lipid Nanoparticles (SLN) for the first time in late 1991 to be a substitute transporter system to what known old colloidal carriers, like emulsions, liposomes, and polymeric micro- and nanoparticles. SLN has merits and potentialities of Classical structures except avoiding some of their common and known disadvantages. This paper reviews SLN production techniques, The integration of drugs, the capacity to load and the release of drugs, with particular emphasis on drug discharge techniques. Issues relating to the introduction of the SLN into the pharmaceutical industry, like the excipients position.
From the very beginning a special and wide interest paid to Lipid nanoparticles (LNPs) during the last decade. Nanostructured lipid transporters strong lipid nanoparticles (SLNs) become the most two essential forms of nanoparticles formed from lipids. SLNs were designed to be able to overcome certain restrictions types of colloidal vectors, like liposomes, emulsions, and polymeric nanoparticles as they possess bright sides like strong discharge profile and guided distribution of drugs with the most perfect physical health. NLCs will amend the SLNs in the next generation of lipid nanoparticles in a way that enhances stability, safety and capacity loading.
This paper focuses on methods to reduce toxic effects using advanced production techniques such as homogenization and solvent evaporation. As it facilitates way for the solid lipid nanoparticles approval as novel or targeted medication distribution system by using several recent analytical techniques like electron microscopy and dynamic light scattering (DLS), differential scanning calorimetry (DSC), nuclear magnetic resonance, atomic force microscopy and their evaluation parameters concurrent with the application.
Conclusion
• Solid lipid nanoparticles (SLNs) represent a transport system alternative to conventional colloidal carriers.
• SLNs combine the advantages of traditional and modern systems if some of their major difficult proceedings are eliminated.
• SLN production techniques include drug incorporation, drug loading and release capacity, with a special focus on drug release methods.
• SLNs as novel system and targeted drugs delivery method through using recent techniques.