Spectrophotometric Determination of Nitrofurantoin in its Bulk and Pharmaceutical Formulations
Abstract
Khawla Salman Abd-Alrasso, Mohammed Sattar, Mazin Nadhim Mosa
Nitrofurantoin is an antibacterial agent works against gram positive and gram-negative bacteria. The main purpose of this work was to determine nitrofurantoin concentration in pure form and marketed pharmaceutical preparations. For this assay two, rapid, accurate and precise spectrophotometric methods were proposed. The methods are based on the reduction of nitrofurantoin by zinc powder in hydrochloric acid medium followed by diazotization of reduced nitrofurantoin and coupling with 8-hydroxy quinolin to give a colored product which is stable, water-soluble and has a maximum absorption at 365 nm (method A). In the second method (method B), the reduced product reacts immediately with p-benzoquinone to give a color product, which has maximum absorbance at 400 nm. The calibration graphs were linear over the concentration range of 0.5-25 and 1-35 μgml-1 for both methods A and B respectively. With molar absorption coefficient of 1.782×104 and 0.897×104 Lmole-1cm-1 for both methods A and B respectively. The proposed methods were applied successfully for commercially available nitrofurantoin dosage forms and the results were statistically compared with those obtained by reference method. Additionally, the results showed no interference of the excipients in the assay process.
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| Pubmed Style Abd-Alrasso KS, Sattar M, Mosa MN. Spectrophotometric Determination of Nitrofurantoin in its Bulk and Pharmaceutical Formulations. SRP. 2020; 11(10): 243-251. doi:10.31838/srp.2020.10.40 Web Style Abd-Alrasso KS, Sattar M, Mosa MN. Spectrophotometric Determination of Nitrofurantoin in its Bulk and Pharmaceutical Formulations. http://www.sysrevpharm.org/?mno=16784 [Access: March 30, 2021]. doi:10.31838/srp.2020.10.40 AMA (American Medical Association) Style Abd-Alrasso KS, Sattar M, Mosa MN. Spectrophotometric Determination of Nitrofurantoin in its Bulk and Pharmaceutical Formulations. SRP. 2020; 11(10): 243-251. doi:10.31838/srp.2020.10.40 Vancouver/ICMJE Style Abd-Alrasso KS, Sattar M, Mosa MN. Spectrophotometric Determination of Nitrofurantoin in its Bulk and Pharmaceutical Formulations. SRP. (2020), [cited March 30, 2021]; 11(10): 243-251. doi:10.31838/srp.2020.10.40 Harvard Style Abd-Alrasso, K. S., Sattar, . M. & Mosa, . M. N. (2020) Spectrophotometric Determination of Nitrofurantoin in its Bulk and Pharmaceutical Formulations. SRP, 11 (10), 243-251. doi:10.31838/srp.2020.10.40 Turabian Style Abd-Alrasso, Khawla Salman, Mohammed Sattar, and Mazin Nadhim Mosa. 2020. Spectrophotometric Determination of Nitrofurantoin in its Bulk and Pharmaceutical Formulations. Systematic Reviews in Pharmacy, 11 (10), 243-251. doi:10.31838/srp.2020.10.40 Chicago Style Abd-Alrasso, Khawla Salman, Mohammed Sattar, and Mazin Nadhim Mosa. "Spectrophotometric Determination of Nitrofurantoin in its Bulk and Pharmaceutical Formulations." Systematic Reviews in Pharmacy 11 (2020), 243-251. doi:10.31838/srp.2020.10.40 MLA (The Modern Language Association) Style Abd-Alrasso, Khawla Salman, Mohammed Sattar, and Mazin Nadhim Mosa. "Spectrophotometric Determination of Nitrofurantoin in its Bulk and Pharmaceutical Formulations." Systematic Reviews in Pharmacy 11.10 (2020), 243-251. Print. doi:10.31838/srp.2020.10.40 APA (American Psychological Association) Style Abd-Alrasso, K. S., Sattar, . M. & Mosa, . M. N. (2020) Spectrophotometric Determination of Nitrofurantoin in its Bulk and Pharmaceutical Formulations. Systematic Reviews in Pharmacy, 11 (10), 243-251. doi:10.31838/srp.2020.10.40 |
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