Studies on microRNA in Pediatric Tuberculosis
Abstract
Ayling Sanjaya, Dwi Yuni Nur Hidayati, Susanthy Djajalaksana, HMS Chandra Kusuma, Sumarno.
Background: Pediatric tuberculosis (TB) is still a major problem in the world leads to adverse complications. Research of microRNA(miRNA) conducted to study and identify specific miRNA expression among active TB children specifically in Indonesia. This suggests that miRNA can be one of the diagnostic tools and therapy for pediatric TB that needs to be developed.
Aims: To study spesific miRNA expression in pediatric active TB in Indonesia using microarray profiling.
Methods: This research was an observational analytic study using a cross sectional study design. The study used whole blood of healthy control children who had never received BCG immunization and children diagnosed with active TB. Identified miRNAs expression profile with microarray analysis.
Results: Four Active TB and 2 healthy control children were included in this study. Extraction of RNA with whole blood were done and profiled with microarray methods. Fold change >2 or <-2 with p-val <0.05. Expression of miRNA passed filter criteria are 251 miRNA with 30 (11.95%) miRNA up-regulated and 221 (88.05%) miRNA down-regulated.
Conclusions: Our study suggests that there are a specific miRNAs identified in active TB children in Indonesia and can be one of the tools to diagnosis and monitoring of therapy that needs to be developed.
How to Cite this Article |
Pubmed Style Ayling Sanjaya, Dwi Yuni Nur Hidayati, Susanthy Djajalaksana, HMS Chandra Kusuma, Sumarno. Studies on microRNA in Pediatric Tuberculosis. SRP. 2020; 11(9): 1143-1149. doi:10.31838/srp.2020.9.165 Web Style Ayling Sanjaya, Dwi Yuni Nur Hidayati, Susanthy Djajalaksana, HMS Chandra Kusuma, Sumarno. Studies on microRNA in Pediatric Tuberculosis. http://www.sysrevpharm.org/?mno=45066 [Access: March 30, 2021]. doi:10.31838/srp.2020.9.165 AMA (American Medical Association) Style Ayling Sanjaya, Dwi Yuni Nur Hidayati, Susanthy Djajalaksana, HMS Chandra Kusuma, Sumarno. Studies on microRNA in Pediatric Tuberculosis. SRP. 2020; 11(9): 1143-1149. doi:10.31838/srp.2020.9.165 Vancouver/ICMJE Style Ayling Sanjaya, Dwi Yuni Nur Hidayati, Susanthy Djajalaksana, HMS Chandra Kusuma, Sumarno. Studies on microRNA in Pediatric Tuberculosis. SRP. (2020), [cited March 30, 2021]; 11(9): 1143-1149. doi:10.31838/srp.2020.9.165 Harvard Style Ayling Sanjaya, Dwi Yuni Nur Hidayati, Susanthy Djajalaksana, HMS Chandra Kusuma, Sumarno (2020) Studies on microRNA in Pediatric Tuberculosis. SRP, 11 (9), 1143-1149. doi:10.31838/srp.2020.9.165 Turabian Style Ayling Sanjaya, Dwi Yuni Nur Hidayati, Susanthy Djajalaksana, HMS Chandra Kusuma, Sumarno. 2020. Studies on microRNA in Pediatric Tuberculosis. Systematic Reviews in Pharmacy, 11 (9), 1143-1149. doi:10.31838/srp.2020.9.165 Chicago Style Ayling Sanjaya, Dwi Yuni Nur Hidayati, Susanthy Djajalaksana, HMS Chandra Kusuma, Sumarno. "Studies on microRNA in Pediatric Tuberculosis." Systematic Reviews in Pharmacy 11 (2020), 1143-1149. doi:10.31838/srp.2020.9.165 MLA (The Modern Language Association) Style Ayling Sanjaya, Dwi Yuni Nur Hidayati, Susanthy Djajalaksana, HMS Chandra Kusuma, Sumarno. "Studies on microRNA in Pediatric Tuberculosis." Systematic Reviews in Pharmacy 11.9 (2020), 1143-1149. Print. doi:10.31838/srp.2020.9.165 APA (American Psychological Association) Style Ayling Sanjaya, Dwi Yuni Nur Hidayati, Susanthy Djajalaksana, HMS Chandra Kusuma, Sumarno (2020) Studies on microRNA in Pediatric Tuberculosis. Systematic Reviews in Pharmacy, 11 (9), 1143-1149. doi:10.31838/srp.2020.9.165 |
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