Study the apoptotic effect of N_butanol extract of Urtica dioica on T24 bladder cancer cell line

Abstract

AHMED ABDULAZIZ AHMED, DR. YASER MUSTAFA KAMAL, DR. BAYDAA HAMEED ABDULLA

Background: Cancer is wide spread disease nowadays affected large number of human .Bladder cancer affected tissue of the bladder and can be metastases to other part of the body .There are many risk factor for bladder cancer include smoking ,family history and radiation .Doxorubicine is one of anticancer agent that used in treatment of Bladder cancer .Urticasea is a family of plant known for their medicinal activity from folk medicine .Urtica dioica is a member of urticasea and it is known for it is anticancer activity .One of most mechanism of anticancer agent is to induce apoptosis in cell. Methods: in the present study we investigate the apoptosis effect of N_ butanol extract of urtica dioica against T24 bladder cancer cell line. Results: The result show increase in the apoptotic effect on the cell by increasing the concentration of extract. Conclusion: The N_ butanol extract of urtica dioica show significant apoptotic effect on T24 bladder cancer cell line