Study the Effect of Rubia Cordifolia Extract on Different Type of Cancer Cell Lines and Different Microbial

Abstract

Zahraa Ahmed Okhti, Basma Talib Al-Sudani, Mayssaa E. Abdalah

Rubia cordifolia (Manjistha, Indian madder) is a plant in the Rubiaceae coffee family distributed in the lower Himalayas, India, Indonesia, Sri Lanka and Japan. It was mainly used as a red pigment, R. Cordifolia can be used for the management of jaundice in Ayurvedic medicine., inflammation of the joints, and cough. R. Cordifolia is becoming increasingly popular in western culture as an alternative treatment for skin disease such as psoriasis, eczema and dermatitis. Past studies have also shown R. Cordifolia is a promising regulator of the spread of breast cancer cells.This research aims to find a solution to conditions such as cancer and multi-drug resistant bacteria that are difficult to treat and fungi by using R.Cordifolia aqueous root extract. Methods used in this inquiry to assess the antimicrobial and anticancer effects of low concentration R. cordifolia aqueous extracts were MTT assay on three cancer cell lines (HepG2, BxPC-3 and MCF-7) and the minimum inhibitory concentration MIC for antimicrobial susceptibility against six microorganisms,three are bacteria (P.aeruginosa (Pseudomonas aeruginosa),E. coli ( Escherichia coli) and B.subtilis (Bacillus subtilis) and three are antibiotic resistant fungi (F. oxysporum, T. basicola and T. phaseolina). The findings indicate that R. Cordifolia In addition to its function as an antimicrobial and antifungal agent, it may have a potential use as an adjunct therapy to pancreatic, liver and breast cancer., as demonstrated in this study against Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis and F. oxysporum, T. basicola and T. phaseolina strains