Synthesis and Biological Activities of 3,5-Disubstituted-4-Hydroxycinnamic Acids Linked to a Functionalized Coumarin

Abstract

Mahmood Khudhayer Oglah, Moath Kahtan Bashir, Yasser Fakri Mustafa, Eman Tareq Mohammed, Raghad Riyadh Khalil

ABSTRACT As part of our interest in the coumarin chemical nucleus, a series of 3,5-disubstituted-4-hydroxycinnamic acids to which 6-hydroxy-7- methoxy-4-methyl-3-isopropylcoumarin is grafted was synthesized via a straightforward synthetic method. Chemical identities of the synthesized conjugates were specified by analyzing their FTIR, 1HNMR, and 13C-NMR spectra. Three biological activities were investigated for the final products along with that of the functionalized coumarin itself, which are: antioxidant, exploratory antitumor, and antimicrobial activities. The first activity was screened via DPPH test, while the second one was tested by a well-documented MTT assay against the following cell lines: SKG, AMN3, MCF-7, and HeLa. Third activity was assessed by an agar disk diffusion method versus four standard bacterial strains and two standard fungal strains. The test pathogens included Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, Haemophilus influenzae, Aspergillus niger, and Candida albicans. The outcomes assumed from the antioxidant activity assay indicated that M2 has a better activity and M5 has less activity than the other synthesized conjugates, the same outcome is documented from studying the exploratory antitumor activity. Concerning the antimicrobial activity, the prepared conjugates, as well as the functionalized coumarin, showed an acceptable activity with an ascendant effect attributed to M1. Based on these findings, it is concluded that the synthesized conjugates M1 and M2may be good candidates as antimicrobial and antitumor agents, respectively. Also, these conjugates may provide new scaffolds for the development of modern therapeutic agents.

How to Cite this Article
Pubmed Style

Oglah MK, Bashir MK, Mustafa YF, Mohammed ET, Khalil RR. Synthesis and Biological Activities of 3,5-Disubstituted-4-Hydroxycinnamic Acids Linked to a Functionalized Coumarin. SRP. 2020; 11(6): 717-725.
doi:10.31838/srp.2020.6.106

Web Style

Oglah MK, Bashir MK, Mustafa YF, Mohammed ET, Khalil RR. Synthesis and Biological Activities of 3,5-Disubstituted-4-Hydroxycinnamic Acids Linked to a Functionalized Coumarin. http://www.sysrevpharm.org/?mno=118820 [Access: March 29, 2021]. doi:10.31838/srp.2020.6.106

AMA (American Medical Association) Style

Oglah MK, Bashir MK, Mustafa YF, Mohammed ET, Khalil RR. Synthesis and Biological Activities of 3,5-Disubstituted-4-Hydroxycinnamic Acids Linked to a Functionalized Coumarin. SRP. 2020; 11(6): 717-725. doi:10.31838/srp.2020.6.106



Vancouver/ICMJE Style

Oglah MK, Bashir MK, Mustafa YF, Mohammed ET, Khalil RR. Synthesis and Biological Activities of 3,5-Disubstituted-4-Hydroxycinnamic Acids Linked to a Functionalized Coumarin. SRP. (2020), [cited March 29, 2021]; 11(6): 717-725. doi:10.31838/srp.2020.6.106



Harvard Style

Oglah, M. K., Bashir, . M. K., Mustafa, . Y. F., Mohammed, . E. T. & Khalil, . R. R. (2020) Synthesis and Biological Activities of 3,5-Disubstituted-4-Hydroxycinnamic Acids Linked to a Functionalized Coumarin. SRP, 11 (6), 717-725. doi:10.31838/srp.2020.6.106



Turabian Style

Oglah, Mahmood Khudhayer, Moath Kahtan Bashir, Yasser Fakri Mustafa, Eman Tareq Mohammed, and Raghad Riyadh Khalil. 2020. Synthesis and Biological Activities of 3,5-Disubstituted-4-Hydroxycinnamic Acids Linked to a Functionalized Coumarin. Systematic Reviews in Pharmacy, 11 (6), 717-725. doi:10.31838/srp.2020.6.106



Chicago Style

Oglah, Mahmood Khudhayer, Moath Kahtan Bashir, Yasser Fakri Mustafa, Eman Tareq Mohammed, and Raghad Riyadh Khalil. "Synthesis and Biological Activities of 3,5-Disubstituted-4-Hydroxycinnamic Acids Linked to a Functionalized Coumarin." Systematic Reviews in Pharmacy 11 (2020), 717-725. doi:10.31838/srp.2020.6.106



MLA (The Modern Language Association) Style

Oglah, Mahmood Khudhayer, Moath Kahtan Bashir, Yasser Fakri Mustafa, Eman Tareq Mohammed, and Raghad Riyadh Khalil. "Synthesis and Biological Activities of 3,5-Disubstituted-4-Hydroxycinnamic Acids Linked to a Functionalized Coumarin." Systematic Reviews in Pharmacy 11.6 (2020), 717-725. Print. doi:10.31838/srp.2020.6.106



APA (American Psychological Association) Style

Oglah, M. K., Bashir, . M. K., Mustafa, . Y. F., Mohammed, . E. T. & Khalil, . R. R. (2020) Synthesis and Biological Activities of 3,5-Disubstituted-4-Hydroxycinnamic Acids Linked to a Functionalized Coumarin. Systematic Reviews in Pharmacy, 11 (6), 717-725. doi:10.31838/srp.2020.6.106

Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran SRP. 2020; 11(1): 14-22 » doi: 10.5530/srp.2019.1.3
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova SRP. 2019; 10(1): 112-117 » doi: 10.5530/srp.2019.1.19
Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review Karle Pravin P, Dhawale Shashikant C SRP. 2019; 10(1): 11-14 » doi: 0.5530/srp.2019.1.2
  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar SRP. 2019; 10(1): 20-25 » doi: 10.5530/srp.2019.1.4
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi SRP. 2019; 10(1): 15-19 » doi: 10.5530/srp.2019.1.3