Synthesis and Biological Activity of Some New Thiazolidinone Derivatives
Abstract
Kawther A.Alheety, Nebras M. Jamel, Jumbad H. Tomma
The compound [G1] was prepared from the reaction of thiosemicarbazide with para-hydroxyphenylmethyl ketone in ethanol as a solvent. Then by sequence reactions prepared [G2] and [G3] compounds. The compound [G4] reaction with ethyl acetoacetoneto synthesized compound [G6] and acetyl acetone to synthesized compound [G5]. Reaction the [G3] with two different types of aldehydes in the present of pipredine to form new alkenes compounds [G7]and [G8].The compound [G3] reacted with hydrazine hydrate to formation[G4] with present the hydrazine hydrade 80% in (10) ml of absolute ethanol. Latter the compound [G4]reacted with different aldehydes with present the glacial acetic acid and the solvent was ethanol to formed the Schiff bases compounds[G9] and [G10]. All the prepared compounds were characterized by FT-IR, 1H-NMR spectra, also biologically activity evaluated, the synthesized derivatives have been screened for their two species of bacteria were used in this study as tested organisms. These are Escherichia Coli (Gram negative) and staphylococcus (Gram positive).
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| Pubmed Style Kawther A.Alheety, Nebras M. Jamel, Jumbad H. Tomma. Synthesis and Biological Activity of Some New Thiazolidinone Derivatives. SRP. 2020; 11(3): 490-494. doi:10.5530/srp.2020.3.62 Web Style Kawther A.Alheety, Nebras M. Jamel, Jumbad H. Tomma. Synthesis and Biological Activity of Some New Thiazolidinone Derivatives. http://www.sysrevpharm.org/?mno=94584 [Access: March 29, 2021]. doi:10.5530/srp.2020.3.62 AMA (American Medical Association) Style Kawther A.Alheety, Nebras M. Jamel, Jumbad H. Tomma. Synthesis and Biological Activity of Some New Thiazolidinone Derivatives. SRP. 2020; 11(3): 490-494. doi:10.5530/srp.2020.3.62 Vancouver/ICMJE Style Kawther A.Alheety, Nebras M. Jamel, Jumbad H. Tomma. Synthesis and Biological Activity of Some New Thiazolidinone Derivatives. SRP. (2020), [cited March 29, 2021]; 11(3): 490-494. doi:10.5530/srp.2020.3.62 Harvard Style Kawther A.Alheety, Nebras M. Jamel, Jumbad H. Tomma (2020) Synthesis and Biological Activity of Some New Thiazolidinone Derivatives. SRP, 11 (3), 490-494. doi:10.5530/srp.2020.3.62 Turabian Style Kawther A.Alheety, Nebras M. Jamel, Jumbad H. Tomma. 2020. Synthesis and Biological Activity of Some New Thiazolidinone Derivatives. Systematic Reviews in Pharmacy, 11 (3), 490-494. doi:10.5530/srp.2020.3.62 Chicago Style Kawther A.Alheety, Nebras M. Jamel, Jumbad H. Tomma. "Synthesis and Biological Activity of Some New Thiazolidinone Derivatives." Systematic Reviews in Pharmacy 11 (2020), 490-494. doi:10.5530/srp.2020.3.62 MLA (The Modern Language Association) Style Kawther A.Alheety, Nebras M. Jamel, Jumbad H. Tomma. "Synthesis and Biological Activity of Some New Thiazolidinone Derivatives." Systematic Reviews in Pharmacy 11.3 (2020), 490-494. Print. doi:10.5530/srp.2020.3.62 APA (American Psychological Association) Style Kawther A.Alheety, Nebras M. Jamel, Jumbad H. Tomma (2020) Synthesis and Biological Activity of Some New Thiazolidinone Derivatives. Systematic Reviews in Pharmacy, 11 (3), 490-494. doi:10.5530/srp.2020.3.62 |
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