Synthesis, Characterization, and Antibacterial Study of New Ligands Derived from Nalidixic acid
Dunya AL-Duhaidahawi, Hanaa Jaffer AlKabee, Meison Abdulbary, Hayder H. AL-Ghuraibawi.
A novel compounds of nalidixic acid derivatives were synthesized by a coupling reaction with 2-aminothiazole-5-carbaldehyde using DIC as coupling reagent and HOBt as racemization suppressant then the product of reaction treated with different amine tail like 2-(methylthio) Ethan amine that result in compound 1 while refluxing with 2-(4-methyl piperazine-1-yl) Ethan amine and 2-(pyrrolidine-1-yl) Ethan amine results in compound 2 and 4 respectively. All the synthesized compounds were adequately identified by spectral studies utilizing IR and elemental analysis and assessed for their in vitro antibacterial activity in contradiction of different type of bacteria. All the tested molecules against bacterial strains compared with the nalidixic acid as a reference drug in this study. Results indicated that compounds 1, 2 & 4 have good antibacterial activities compared to standard drug especially as they were found to have promising activity against Bacillus and to be as effective as nalidixic acid toward psudomonus and E coli.