Synthesis, Characterization, Antimicrobial Investigation and in-silico Screening of Di-imines Derived from 4,4?-Diaminoazobenzene
Abstract
Amjid Iqbal, Shan Hazoor.
Eight new di-imines were synthesized in good yield simply by refluxing substituted benzaldehyde/pyridyl carboxaldehydes and diamine using methanol. Diamine was synthesized from acetanilide. The chemical structure of di-imines were confirmed by FT-IR, NMR, MS and elemental microanalysis. The compounds were assayed for anti-bacterial and anti-fungal activities by the disc diffusion method. Also, the in-silico ADMET study, logP prediction, biological activity score, molecular properties and Drug likeness score of these compounds were determined using Pre-ADMET, molinspiration and Molsoft online softwares respectively. ADMET study revealed that from absorption parameters human intestinal absorption value for all the synthesized di-imine was good. Similarly, the distribution property in plasma protein binding predicted that these di-imines have greater binding ability. The physical properties were determined using MolSoft. These physical properties were used to evaluate the oral bioavailability of compounds using “Lipinski’s rule of Five” and Molecular polar surface area for drug transportation through membranes penetration.
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| Pubmed Style AI, Hazoor S. Synthesis, Characterization, Antimicrobial Investigation and in-silico Screening of Di-imines Derived from 4,4′-Diaminoazobenzene. SRP. 2020; 11(7): 204-211. doi:10.31838/srp.2020.7.32 Web Style AI, Hazoor S. Synthesis, Characterization, Antimicrobial Investigation and in-silico Screening of Di-imines Derived from 4,4′-Diaminoazobenzene. http://www.sysrevpharm.org/?mno=125738 [Access: March 29, 2021]. doi:10.31838/srp.2020.7.32 AMA (American Medical Association) Style AI, Hazoor S. Synthesis, Characterization, Antimicrobial Investigation and in-silico Screening of Di-imines Derived from 4,4′-Diaminoazobenzene. SRP. 2020; 11(7): 204-211. doi:10.31838/srp.2020.7.32 Vancouver/ICMJE Style AI, Hazoor S. Synthesis, Characterization, Antimicrobial Investigation and in-silico Screening of Di-imines Derived from 4,4′-Diaminoazobenzene. SRP. (2020), [cited March 29, 2021]; 11(7): 204-211. doi:10.31838/srp.2020.7.32 Harvard Style , A. I. & Hazoor, . S. (2020) Synthesis, Characterization, Antimicrobial Investigation and in-silico Screening of Di-imines Derived from 4,4′-Diaminoazobenzene. SRP, 11 (7), 204-211. doi:10.31838/srp.2020.7.32 Turabian Style , Amjid Iqbal, and Shan Hazoor. 2020. Synthesis, Characterization, Antimicrobial Investigation and in-silico Screening of Di-imines Derived from 4,4′-Diaminoazobenzene. Systematic Reviews in Pharmacy, 11 (7), 204-211. doi:10.31838/srp.2020.7.32 Chicago Style , Amjid Iqbal, and Shan Hazoor. "Synthesis, Characterization, Antimicrobial Investigation and in-silico Screening of Di-imines Derived from 4,4′-Diaminoazobenzene." Systematic Reviews in Pharmacy 11 (2020), 204-211. doi:10.31838/srp.2020.7.32 MLA (The Modern Language Association) Style , Amjid Iqbal, and Shan Hazoor. "Synthesis, Characterization, Antimicrobial Investigation and in-silico Screening of Di-imines Derived from 4,4′-Diaminoazobenzene." Systematic Reviews in Pharmacy 11.7 (2020), 204-211. Print. doi:10.31838/srp.2020.7.32 APA (American Psychological Association) Style , A. I. & Hazoor, . S. (2020) Synthesis, Characterization, Antimicrobial Investigation and in-silico Screening of Di-imines Derived from 4,4′-Diaminoazobenzene. Systematic Reviews in Pharmacy, 11 (7), 204-211. doi:10.31838/srp.2020.7.32 |
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