Synthesis, Characterization of Ibuprofen N-Acyl-1,3,4-Oxadiazole Derivatives and Anticancer Activity against MCF-7 Cell Line

Abstract

Mustafa Q. Ali Alderawy, Leaqaa A. Raheem Alrubaie, Falah Hassan Sheri

Purpose: To synthesis and investigate the anti- cancer activity of some ibuprofen-oxadiazole derivatives as a molecular hybrid model. Method: Five derivatives of Ibuprofen-Oxadiazole have been synthesized from ibuprofen through several steps to obtained and identified the final derivatives by analytical techniques, FTIR, 1HNMR and elemental analysis. All the derivatives were evaluated for their anticancer activity by MTT assay. The possibility to improve the physical properties of ibuprofen and also give an additional biological activity, so our research was an application of this idea. The synthesized derivatives were studied theoretically, and some chemical parameters were calculated using the PM3 method to study the stability of derivatives IV (a-e). Results: showed that the synthesized derivatives revealed promising in vitro cytotoxicity. Conclusion: The molecular hybrid system of ibuprofen-oxadizole has demonstrated additional biological effectiveness for ibuprofen.