Synthesis Of New Compounds Derived From Dapsone And Study Their Biological Activity
Abstract
Tareq K. Ibraheem, and Ziad T I Alkayar, Mohammed A M Al-badri
The new compounds were synthesized by treating the drug dapsone 1 with chloroacetyl chloride in the presence of base. Both amino groups are acylated to give compound 6. The symmetrical acylated product then treated with Aniline, Saccharine, p-Bromoaniline, m-Bromoaniline, p-Hydroxyaniline, m-Hydroxyaniline, o-Phenylenediamine and m-Phenylenediamine to give compounds 7(a-h). All the new compounds have scanned for their biological activities toward gram negative (Esherichia coli, Proteus mirabilis) and gram positive (Streptococcus pneumoniae, Mycobacterium tuberculosis) bacteria, the synthesized derivatives gave moderate to good activity as compared to the parent drug toward both mentioned types of bacteria.
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| Pubmed Style Tareq K. Ibraheem, and Ziad T I Alkayar, Mohammed A M Al-badri. Synthesis Of New Compounds Derived From Dapsone And Study Their Biological Activity. SRP. 2021; 12(1): 840-843. doi:10.31838/srp.2021.1.118 Web Style Tareq K. Ibraheem, and Ziad T I Alkayar, Mohammed A M Al-badri. Synthesis Of New Compounds Derived From Dapsone And Study Their Biological Activity. http://www.sysrevpharm.org/?mno=45463 [Access: March 29, 2021]. doi:10.31838/srp.2021.1.118 AMA (American Medical Association) Style Tareq K. Ibraheem, and Ziad T I Alkayar, Mohammed A M Al-badri. Synthesis Of New Compounds Derived From Dapsone And Study Their Biological Activity. SRP. 2021; 12(1): 840-843. doi:10.31838/srp.2021.1.118 Vancouver/ICMJE Style Tareq K. Ibraheem, and Ziad T I Alkayar, Mohammed A M Al-badri. Synthesis Of New Compounds Derived From Dapsone And Study Their Biological Activity. SRP. (2021), [cited March 29, 2021]; 12(1): 840-843. doi:10.31838/srp.2021.1.118 Harvard Style Tareq K. Ibraheem, and Ziad T I Alkayar, Mohammed A M Al-badri (2021) Synthesis Of New Compounds Derived From Dapsone And Study Their Biological Activity. SRP, 12 (1), 840-843. doi:10.31838/srp.2021.1.118 Turabian Style Tareq K. Ibraheem, and Ziad T I Alkayar, Mohammed A M Al-badri. 2021. Synthesis Of New Compounds Derived From Dapsone And Study Their Biological Activity. Systematic Reviews in Pharmacy, 12 (1), 840-843. doi:10.31838/srp.2021.1.118 Chicago Style Tareq K. Ibraheem, and Ziad T I Alkayar, Mohammed A M Al-badri. "Synthesis Of New Compounds Derived From Dapsone And Study Their Biological Activity." Systematic Reviews in Pharmacy 12 (2021), 840-843. doi:10.31838/srp.2021.1.118 MLA (The Modern Language Association) Style Tareq K. Ibraheem, and Ziad T I Alkayar, Mohammed A M Al-badri. "Synthesis Of New Compounds Derived From Dapsone And Study Their Biological Activity." Systematic Reviews in Pharmacy 12.1 (2021), 840-843. Print. doi:10.31838/srp.2021.1.118 APA (American Psychological Association) Style Tareq K. Ibraheem, and Ziad T I Alkayar, Mohammed A M Al-badri (2021) Synthesis Of New Compounds Derived From Dapsone And Study Their Biological Activity. Systematic Reviews in Pharmacy, 12 (1), 840-843. doi:10.31838/srp.2021.1.118 |
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