Synthesis, Spectral and Biological Studies of Co (III), Ni (II), and Cu (II) Complexes with New Heterocyclic Ligand Derived from Azo dye
Abstract
Makarim A. Mahdi, Layth S. Jasim and Moslem H. Mohamed
Amidazole is an important type of aromatic compounds heterogeneous ring, as it enters in many areas, including chemical and biological, due to the high therapeutic property of amidazole and the wide range of its clinical drugs As the researchers proceeded to prepare a large number of chemical treatments, including Antifungal, Antioxidant[1], anti-inflammatory[2], antimicrobial[3], anticancer[4] and anti-tumor agents[5]. The imidazole ring is present in many natural products and in the human body, among which are vitamin B7 or biotin[6], and there is an imidazole ring in medicines to treat certain diseases such as cimetidin [7]which is used. In the treatment of stomach and duodenal wounds and the drug Metronidazole, or as it is known commercially as Flagyl[8, 9]. In this study, we report the preparation, identification of new ligand 2- [2--(5- chloro carboxy phenyl) azo] 5-methyl imidazole (5-MeCPAI) and its complexes Co (III), Ni (II) and Cu (II) ions. The synthesis compounds were studied by various spectral analysis and screened for their biological activities against Klebsilla pneumonia, streptococcus as antibacterial and Aspergillus Niger. as antifungal. Moreover, the study of Cu (II) complex of prescription drug anticancer by using the lines of breast cancer cells and compared with line of the normal cells by MTT assay.
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| Pubmed Style Makarim A. Mahdi, Layth S. Jasim and Moslem H. Mohamed. Synthesis, Spectral and Biological Studies of Co (III), Ni (II), and Cu (II) Complexes with New Heterocyclic Ligand Derived from Azo dye. SRP. 2021; 12(1): 426-434. doi:10.31838/srp.2021.1.63 Web Style Makarim A. Mahdi, Layth S. Jasim and Moslem H. Mohamed. Synthesis, Spectral and Biological Studies of Co (III), Ni (II), and Cu (II) Complexes with New Heterocyclic Ligand Derived from Azo dye. http://www.sysrevpharm.org/?mno=36843 [Access: March 29, 2021]. doi:10.31838/srp.2021.1.63 AMA (American Medical Association) Style Makarim A. Mahdi, Layth S. Jasim and Moslem H. Mohamed. Synthesis, Spectral and Biological Studies of Co (III), Ni (II), and Cu (II) Complexes with New Heterocyclic Ligand Derived from Azo dye. SRP. 2021; 12(1): 426-434. doi:10.31838/srp.2021.1.63 Vancouver/ICMJE Style Makarim A. Mahdi, Layth S. Jasim and Moslem H. Mohamed. Synthesis, Spectral and Biological Studies of Co (III), Ni (II), and Cu (II) Complexes with New Heterocyclic Ligand Derived from Azo dye. SRP. (2021), [cited March 29, 2021]; 12(1): 426-434. doi:10.31838/srp.2021.1.63 Harvard Style Makarim A. Mahdi, Layth S. Jasim and Moslem H. Mohamed (2021) Synthesis, Spectral and Biological Studies of Co (III), Ni (II), and Cu (II) Complexes with New Heterocyclic Ligand Derived from Azo dye. SRP, 12 (1), 426-434. doi:10.31838/srp.2021.1.63 Turabian Style Makarim A. Mahdi, Layth S. Jasim and Moslem H. Mohamed. 2021. Synthesis, Spectral and Biological Studies of Co (III), Ni (II), and Cu (II) Complexes with New Heterocyclic Ligand Derived from Azo dye. Systematic Reviews in Pharmacy, 12 (1), 426-434. doi:10.31838/srp.2021.1.63 Chicago Style Makarim A. Mahdi, Layth S. Jasim and Moslem H. Mohamed. "Synthesis, Spectral and Biological Studies of Co (III), Ni (II), and Cu (II) Complexes with New Heterocyclic Ligand Derived from Azo dye." Systematic Reviews in Pharmacy 12 (2021), 426-434. doi:10.31838/srp.2021.1.63 MLA (The Modern Language Association) Style Makarim A. Mahdi, Layth S. Jasim and Moslem H. Mohamed. "Synthesis, Spectral and Biological Studies of Co (III), Ni (II), and Cu (II) Complexes with New Heterocyclic Ligand Derived from Azo dye." Systematic Reviews in Pharmacy 12.1 (2021), 426-434. Print. doi:10.31838/srp.2021.1.63 APA (American Psychological Association) Style Makarim A. Mahdi, Layth S. Jasim and Moslem H. Mohamed (2021) Synthesis, Spectral and Biological Studies of Co (III), Ni (II), and Cu (II) Complexes with New Heterocyclic Ligand Derived from Azo dye. Systematic Reviews in Pharmacy, 12 (1), 426-434. doi:10.31838/srp.2021.1.63 |
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