The Association between Alfacalcidol (1-alpha-hydroxyvitamin D3) and Oxidative Stress in Patients with Type II Diabetic Nephropathy

Abstract

Ahmed Khalid Aldhalmi, Ali Jihad Hemid Al-Athari.

Diabetic nephropathy is the major risk factor for cardiovascular disease among young adults with DM Type (II), one of the more common microvascular complications, which influence the survival and quality of life of the patient. Research currently is underway to establish if there is a link between the effect of 1-alpha (OH) D3 and Type II Diabetic Nephropathy patients and whether the Type II regulated diabetic nephropathy patient is related to 1-alpha (OH) D3 and to oxidative stress conditions. In diabetic patients, no relationship has been established between the effect of alfacalcidol and antioxidant and/or prooxidant. The clinical applicability of our research will be to identify a correlation between diabetic nephropathy and oxidative stress. This will lead to the development of new guidelines to assess if this vitamin can be substituted or supplemented to treat this high mortality disease in patients with type II diabetes mellitus.