The Correlation between Fibroblast Growth Factor 23 (FGF23) and Iron Profile in Chronic Kidney Disease Patients on Dialysis with Anemia
Abstract
Mohammad Rudiansyah, Leonardo Lubis, Ria Bandiara, Bernadet Maria Sanjaya, Hendra Wana Nurâamin, Huldani, Abdul Hadi Martakusumah, Harun Achmad, Rully Marsis Amirullah Roesli, Dedi Rachmadi
ABSTRACT Patients with chronic kidney disease on dialysis (CKD-5D) often develop various complications, one of them is iron deficiency anemia. Iron is needed as a raw material for the formation of red blood cells. Iron deficiency increases levels of Fibroblast Growth Factor 23 (FGF23). In CKD-5D patients, the functional iron deficiency often occurs and FGF23 levels increase. FGF23 levels can be a poor prognosis in CKD-5D. This study aims to find out the correlation between FGF23 with hemoglobin level, serum iron, total iron-binding capacity, and ferritin level in CKD-5D patients with anemia. This study was cross-sectional. Subjects were CKD patients undergoing routine hemodialysis (HD) twice a week at least 3 months, aged >18 years, anemia (hemoglobin levels <13 g/dL (men) and <12gr/dL (women)) and were willing to participate in the study by signing an informed consent letter in the Hemodialysis Unit of Hasan Sadikin General Hospital, Bandung. The statistical test used was Pearson correlation if the data were normally distributed and Spearman Rank Analysis if the data were not normally distributed. There were 181 patients with CKD-5D, 137 patients had complete data and met 97 inclusion and exclusion criteria. Seventy-five patients were taken randomly from 97 patients to become subjects of the study. The results showed there were significant correlations between levels of Total Iron-Binding Capacity (TIBC) with FGF23 (r = 0.249, p = 0.015) and levels of Transferrin Saturation with FGF23 (r = -0.259, p = 0.012). There were no statistical correlation between hemoglobin levels with FGF23 (r = 0.025, p = 0.417) and levels of Serum Iron (SI) with FGF23 (r = -0.060, p = 0.306). There were correlations between FGF23 with TIBC and Transferrin Saturation levels, and there were no significant correlations between FGF23 with hemoglobin and SI levels in CKD5D patients with anemia.
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| Pubmed Style Mohammad Rudiansyah, Leonardo Lubis, Ria Bandiara, Bernadet Maria Sanjaya, Hendra Wana Nur'amin, Huldani, Abdul Hadi Martakusumah, Harun Achmad, Rully Marsis Amirullah Roesli, Dedi Rachmadi. The Correlation between Fibroblast Growth Factor 23 (FGF23) and Iron Profile in Chronic Kidney Disease Patients on Dialysis with Anemia. SRP. 2020; 11(6): 780-784. doi:10.31838/srp.2020.6.114 Web Style Mohammad Rudiansyah, Leonardo Lubis, Ria Bandiara, Bernadet Maria Sanjaya, Hendra Wana Nur'amin, Huldani, Abdul Hadi Martakusumah, Harun Achmad, Rully Marsis Amirullah Roesli, Dedi Rachmadi. The Correlation between Fibroblast Growth Factor 23 (FGF23) and Iron Profile in Chronic Kidney Disease Patients on Dialysis with Anemia. http://www.sysrevpharm.org/?mno=119061 [Access: March 29, 2021]. doi:10.31838/srp.2020.6.114 AMA (American Medical Association) Style Mohammad Rudiansyah, Leonardo Lubis, Ria Bandiara, Bernadet Maria Sanjaya, Hendra Wana Nur'amin, Huldani, Abdul Hadi Martakusumah, Harun Achmad, Rully Marsis Amirullah Roesli, Dedi Rachmadi. The Correlation between Fibroblast Growth Factor 23 (FGF23) and Iron Profile in Chronic Kidney Disease Patients on Dialysis with Anemia. SRP. 2020; 11(6): 780-784. doi:10.31838/srp.2020.6.114 Vancouver/ICMJE Style Mohammad Rudiansyah, Leonardo Lubis, Ria Bandiara, Bernadet Maria Sanjaya, Hendra Wana Nur'amin, Huldani, Abdul Hadi Martakusumah, Harun Achmad, Rully Marsis Amirullah Roesli, Dedi Rachmadi. The Correlation between Fibroblast Growth Factor 23 (FGF23) and Iron Profile in Chronic Kidney Disease Patients on Dialysis with Anemia. SRP. (2020), [cited March 29, 2021]; 11(6): 780-784. doi:10.31838/srp.2020.6.114 Harvard Style Mohammad Rudiansyah, Leonardo Lubis, Ria Bandiara, Bernadet Maria Sanjaya, Hendra Wana Nur'amin, Huldani, Abdul Hadi Martakusumah, Harun Achmad, Rully Marsis Amirullah Roesli, Dedi Rachmadi (2020) The Correlation between Fibroblast Growth Factor 23 (FGF23) and Iron Profile in Chronic Kidney Disease Patients on Dialysis with Anemia. SRP, 11 (6), 780-784. doi:10.31838/srp.2020.6.114 Turabian Style Mohammad Rudiansyah, Leonardo Lubis, Ria Bandiara, Bernadet Maria Sanjaya, Hendra Wana Nur'amin, Huldani, Abdul Hadi Martakusumah, Harun Achmad, Rully Marsis Amirullah Roesli, Dedi Rachmadi. 2020. The Correlation between Fibroblast Growth Factor 23 (FGF23) and Iron Profile in Chronic Kidney Disease Patients on Dialysis with Anemia. Systematic Reviews in Pharmacy, 11 (6), 780-784. doi:10.31838/srp.2020.6.114 Chicago Style Mohammad Rudiansyah, Leonardo Lubis, Ria Bandiara, Bernadet Maria Sanjaya, Hendra Wana Nur'amin, Huldani, Abdul Hadi Martakusumah, Harun Achmad, Rully Marsis Amirullah Roesli, Dedi Rachmadi. "The Correlation between Fibroblast Growth Factor 23 (FGF23) and Iron Profile in Chronic Kidney Disease Patients on Dialysis with Anemia." Systematic Reviews in Pharmacy 11 (2020), 780-784. doi:10.31838/srp.2020.6.114 MLA (The Modern Language Association) Style Mohammad Rudiansyah, Leonardo Lubis, Ria Bandiara, Bernadet Maria Sanjaya, Hendra Wana Nur'amin, Huldani, Abdul Hadi Martakusumah, Harun Achmad, Rully Marsis Amirullah Roesli, Dedi Rachmadi. "The Correlation between Fibroblast Growth Factor 23 (FGF23) and Iron Profile in Chronic Kidney Disease Patients on Dialysis with Anemia." Systematic Reviews in Pharmacy 11.6 (2020), 780-784. Print. doi:10.31838/srp.2020.6.114 APA (American Psychological Association) Style Mohammad Rudiansyah, Leonardo Lubis, Ria Bandiara, Bernadet Maria Sanjaya, Hendra Wana Nur'amin, Huldani, Abdul Hadi Martakusumah, Harun Achmad, Rully Marsis Amirullah Roesli, Dedi Rachmadi (2020) The Correlation between Fibroblast Growth Factor 23 (FGF23) and Iron Profile in Chronic Kidney Disease Patients on Dialysis with Anemia. Systematic Reviews in Pharmacy, 11 (6), 780-784. doi:10.31838/srp.2020.6.114 |
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