The Correlation between Hematological Parameters and Transcranial Color Doppler (TCD) with Severity of Acute Ischemic Stroke ? A Cross-Sectional Study

Abstract

Kiking Ritarwan, Iswandi Erwin, Muhammad Yusuf, Oke Rina Ramayani.

To access correlation between both hematological profile and Transcortical Color Doppler (TCD) ultrasonography with stroke severity by using National Institute of Health Stroke Scale (NIHSS) score. This cross-sectional study was conducted from August to December 2016. Hematological profiles (hemoglobin count [Hb], hematocrit [Hct], platelet, and erythrocyte sedimentation rate [ESR]), TCD ultrasound measurements (mean flow velocity [MFV], peak systolic [PS], end-diastolic velocity [EDV], and pulsatility index [PI]) on middle cerebral artery (MCA) and internal carotid artery (ICA), and severity of stroke according to NIHSS score was measured. Both hematological profiles and TCD ultrasound measurements were compared with stroke severity, then test of correlation was conducted. There were 90 patients enrolled in this study. Positive correlation between NIHSS score with Hb (r = 0.519), Hct (r = 0.481), and ESR (r = 0.519). On TCD measurements, negative correlation was found between NIHSS score with MFV and PS on both MCA (r = - 0.615 and r = - 0.336, respectively) and ICA (r = -0.570 and r = - 0.596, respectively), and end-diastolic velocity on ICA (r = -0.477). Positive correlation was found between NIHSS score and pulsatility index on MCA (r = 0.568). There is positive correlation between NIHSS score with hematological parameters (Hb, Hct, and ESR) and PI on MCA. Negative correlation was found between NIHSS score with MFV and PS on both MCA and ICA, and EDV on ICA. The strongest correlation was found to be MFV on MCA.