The Effect of 2% Topical Mupirocin Cream on Biofilm Growth in Double Lumen Catheters in Hemodialysis Patients

Abstract

Astriyani Dyah Febriyanti, Aditiawardana, Widodo, Lindawati Alimsardjono

Double lumen catheter is a known risk factor for Staphylococcus aureus infection and bacteraemia in haemodialysis patients. The objective of this study was to determine the effectiveness of topical 2% mupirocin cream in lowering the growth of the biofilm at the Haemodialysis Installation of Dr. Soetomo Hospital Surabaya. Our research was an analytical quasi-experimental which subject divided into 2 groups equally, control and mupirocin group. Biofilms catheter was examined by tube test method with a nephelometer. Positive biofilm results if ≥0.36 MF, negative if >0.36 MF. Our research was obtained men (37%) and women (63%) with median age 51.3 (20-73 years). The mean duration of catheter insertion was longer in control than in the mupirocin group, 65.16 and 49, respectively (p = 0.005). There were positive biofilm growth results in both groups, 8 subjects (42%) in control group and 3 subjects (16%) in the mupirocin group, respectively. There was significant differences in the growth of biofilm between the two groups (p = 0.036; rd = 26%). Topical 2% mupirocin cream applied to the exit site CDL significantly reduced the biofilm growth in haemodialysis patients.