The Efficacy and Safety of Antivirus Drugs for COVID-19: A Systematic Review

Abstract

Muhammad Ardi Munir, Hendra Kuganda, Amirah Basry.

Corona Virus Disease 2019 (COVID-9) is an acute respiratory infection caused by extreme acute coronavirus-2 (SARS-CoV-2) respiratory syndrome. WHO has designated COVID-19 as a pandemic with a very high mortality rate and increasing very rapidly, in only 3 months COVID- 19 has infected 1.133046 people and in many cases only 14 days COVID-19 has caused death? With very high mortality and mordibility rates, no effective and safe of antivirus treatment has yet been found to cure COVID-19, so research is needed to find the most effective and safe of antivirus drugs to cure COVID-19. To know the best and safe of antivirus medication to cure COVID-19. This research uses a structured analysis focused on preferred reporting items for systematic reviews and meta-analyzes (PRISMA) in order to classify all existing literature with appropriate keywords. The database using PRISMA (Preferred Reporting Items for Systematic Reviews & Meta Analyses) for instruments and used flowcharts based on the 2009 PRISMA checklist and based on inclusion and exclusion criteria, we found 6 anti-virus drugs used to treat SARS-CoV-1 or MERS-CoV and very potential to treat COVID-19, that is Favipiravir (Avigan, Favilavir), Lopinavir and Ritonavir (LPV / RTV; Kaletra) , Neuraminidase inhibitors (eg, oseltamivir), Umifenovir (Arbidol) Remdesivir, and Baloxavir. The most efficacy and safe of anti-virus is Favipiravir because this drug can improve significantly time-to-relief for fever and cough and is associated with manageable adverse effects.