The Influence of Casein Supplementation on CD-4, IL-17, and TNF-? in a Preterm Rattus norvegicus Chorioamnionitis Model
Abstract
Hari Paraton, Sanarto Santoso, Aulanniâam Aulanni'am, Erry Gumilar Dachlan, I W. Arsana Wiyasa, Alifah Wahyu Hariani, Widjiati, Sumarno Reto Prawiro
PROPOSE: This study aims to prove the role of casein supplementation as an immune modulator in response to the CD-4, IL-7, and TNF-α Rattus norvegicus (RN) chorioamnionitis models. METHODS: Thirty-two pregnant RNs divide into four groups. Groups 1 and 2 were given a diet with casein 40g/kg (casein dose 0.4g/day), while groups 3 and 4 a casein diet 200g/kg diet (casein dose 2g/day). Meanwhile, groups 2 and 4 received 100μg/kg body weight lipopolysaccharide (LPS) on day 10th to induce chorioamnionitis. Terminated RN from each group randomly selected under general anesthesia on day 12 and day 14. The assessed CD-4, IL-17, and TNF-α expression semi-quantitatively. The data obtained were analyzed using the ANOVA test.
RESULTS: The concentration of CD-4 was not significantly different (p-value 0.380). The results show that casein supplementation in the preterm RN chorioamnionitis model did not affect the increase in CD-4. However, IL-17 and TNF-α levels differed significantly in the chorioamnionitis group treated with casein supplementation (p-value 0.000).
CONCLUSION: Casein supplementation acts as an immune-modulating response to chorioamnionitis
| How to Cite this Article |
| Pubmed Style Paraton H, Santoso S, Aulanniam A, Dachlan EG, Wiyasa IWA, Hariani AW, Widjiati , Prawiro SR. The Influence of Casein Supplementation on CD-4, IL-17, and TNF-α in a Preterm Rattus norvegicus Chorioamnionitis Model. SRP. 2021; 12(1): 1555-1560. doi:10.31838/srp.2021.1.219 Web Style Paraton H, Santoso S, Aulanniam A, Dachlan EG, Wiyasa IWA, Hariani AW, Widjiati , Prawiro SR. The Influence of Casein Supplementation on CD-4, IL-17, and TNF-α in a Preterm Rattus norvegicus Chorioamnionitis Model. http://www.sysrevpharm.org/?mno=53326 [Access: March 29, 2021]. doi:10.31838/srp.2021.1.219 AMA (American Medical Association) Style Paraton H, Santoso S, Aulanniam A, Dachlan EG, Wiyasa IWA, Hariani AW, Widjiati , Prawiro SR. The Influence of Casein Supplementation on CD-4, IL-17, and TNF-α in a Preterm Rattus norvegicus Chorioamnionitis Model. SRP. 2021; 12(1): 1555-1560. doi:10.31838/srp.2021.1.219 Vancouver/ICMJE Style Paraton H, Santoso S, Aulanniam A, Dachlan EG, Wiyasa IWA, Hariani AW, Widjiati , Prawiro SR. The Influence of Casein Supplementation on CD-4, IL-17, and TNF-α in a Preterm Rattus norvegicus Chorioamnionitis Model. SRP. (2021), [cited March 29, 2021]; 12(1): 1555-1560. doi:10.31838/srp.2021.1.219 Harvard Style Paraton, H., Santoso, . S., Aulanniam, . A., Dachlan, . E. G., Wiyasa, . I. W. A., Hariani, . A. W., Widjiati, . & Prawiro, . S. R. (2021) The Influence of Casein Supplementation on CD-4, IL-17, and TNF-α in a Preterm Rattus norvegicus Chorioamnionitis Model. SRP, 12 (1), 1555-1560. doi:10.31838/srp.2021.1.219 Turabian Style Paraton, Hari, Sanarto Santoso, Aulanni'am Aulanniam, Erry Gumilar Dachlan, I W. Arsana Wiyasa, Alifah Wahyu Hariani, Widjiati, and Sumarno Reto Prawiro. 2021. The Influence of Casein Supplementation on CD-4, IL-17, and TNF-α in a Preterm Rattus norvegicus Chorioamnionitis Model. Systematic Reviews in Pharmacy, 12 (1), 1555-1560. doi:10.31838/srp.2021.1.219 Chicago Style Paraton, Hari, Sanarto Santoso, Aulanni'am Aulanniam, Erry Gumilar Dachlan, I W. Arsana Wiyasa, Alifah Wahyu Hariani, Widjiati, and Sumarno Reto Prawiro. "The Influence of Casein Supplementation on CD-4, IL-17, and TNF-α in a Preterm Rattus norvegicus Chorioamnionitis Model." Systematic Reviews in Pharmacy 12 (2021), 1555-1560. doi:10.31838/srp.2021.1.219 MLA (The Modern Language Association) Style Paraton, Hari, Sanarto Santoso, Aulanni'am Aulanniam, Erry Gumilar Dachlan, I W. Arsana Wiyasa, Alifah Wahyu Hariani, Widjiati, and Sumarno Reto Prawiro. "The Influence of Casein Supplementation on CD-4, IL-17, and TNF-α in a Preterm Rattus norvegicus Chorioamnionitis Model." Systematic Reviews in Pharmacy 12.1 (2021), 1555-1560. Print. doi:10.31838/srp.2021.1.219 APA (American Psychological Association) Style Paraton, H., Santoso, . S., Aulanniam, . A., Dachlan, . E. G., Wiyasa, . I. W. A., Hariani, . A. W., Widjiati, . & Prawiro, . S. R. (2021) The Influence of Casein Supplementation on CD-4, IL-17, and TNF-α in a Preterm Rattus norvegicus Chorioamnionitis Model. Systematic Reviews in Pharmacy, 12 (1), 1555-1560. doi:10.31838/srp.2021.1.219 |
Abstract
PDF
How to cite this article
Related Records