The Protective Effect of Omega3 Against Amikacin- Induced Nephrotoxicity in Rats

Abstract

Afrah Thiab Hlail, Hadeel Rashid Faraj, Wafa S. Abdulredha.

Renal system is vital for total body homeostasis because the kidney plays a principle role in the excretion of metabolic waste products and in the regulation of extracellular fluid volume, electrolyte composition, and acid-base balance. Amikacin induced renal toxicity including a variety of pathophysiological effects i.e. inflammation, specific transporters inhibition ,induction of oxidative stress and vascular alterations.Omega-3 fatty acids are unsaturated fatty acids that have a roles in human physiology including antioxidant and anti-inflammatory effects,. This study was designed to examine the impact of co administration of omega 3 with therapeutic dose of amikacin for 14 days in rats on amikacin nephrotoxic effect. The animals utilized in this study were allocated into 3 groups (eight rats each) as negative control group ,amikacin only group and omega 3 in concomitant with amikacin group .serum creatinine, serum urea ,serum malondialdehyde( MDA) and serum glutathione(GSH) levels were determined. The results showed significant increase (P<0.05) in serum creatinine , urea and malondialdehyde levels and significant decrease (P<0.05) in serum GSH level in amikacin treated group compared to the corresponding level in negative control group. Moreover, significant decrease in serum creatinine, urea, MDA levels and significant increase in GSH level in group receiving omega3 with amikacin in comparison with amikacin treated group. this study demonstrated that co-administration of omega 3 with amikacin for 14 days significantly alleviate the injurious effects of the intended antibiotic on rats' kidneys.