The Relationship between Expressions of Toll-Like Receptor 4 and BODE Index Score in Patients with Chronic Obstruction Pulmonary Disease

Abstract

Ahmed Abdullah Ajrash Al-Khafaji, Yesar MH Al-Shamma, Najah R Hadi, Ali M Janabi.

Chronic obstructive pulmonary disease (COPD) is a group of common medical disorders. Morbidity and mortality rate of this disease are increasing due to lack of both effective treatment and full understanding of pathogenesis and mechanism of this disease. Thus, current study aims to investigate the relationship between the expression of toll-like receptor 4 (TLR4) and BODE index in patient with COPD as a part of potential mechanism in the developing of COPD. This study is a case control study conducted in both Alsadar and Almerjan hospitals. A total of 187 individuals 87 patients with COPD and 100 people without COPD) were selected after application of inclusion and exclusion criteria. Using RT-PCR, the expression of TLR4 was investigated. FEV1/FVCratio was examined using spirometry. There was a significant decrease in the expression of TLR4 among COPD patients when compared with healthy individuals (P < 0.001). COPD patients showed a significant increase in BODE index when compared with control people (P< 0.001). The decrease in the level of TLR4 expression in association with increased BODE index might consider as a suitable indicator for stability and chronicity of the disease. The pulmonary function test is still convenient method for screening and diagnosis of COPD.