The Role of Immunopathology: As Predictor Factors in Patients with Inflammatory Bowel Diseases

Abstract

Kemelbekov Kanatzhan, Kozhakhmetova Ulzhan, Kuzenbayeva Aisulu, Tazhedinova Aigerim, Nurkeshova Elmira.

Recently, significant progress has been made in understanding the pathogenesis of Inflammatory Bowel Diseases (IBD), but to date, their etiology has not been established. As a result, treatment is not always successful, resistance to basic therapies is formed, and severe, life-threatening complications are added.
Identify risk factors for cellular and humoral immunity in patients with inflammatory bowel diseases.The study included the actual material of an open prospective cohort study in parallel groups of 40 patients with UC and CD. The state of cellular immunity was assessed by determining the number of subpopulations of T-lymphocytes (CD4+, CD8+), and NK cells (CD16+). The results obtained allow us to present a possible scenario for the development of pathogenetic relationships as follows: expressing TLR 2,4 initiation or intensification of the inflammatory process in the colon mucosa, and, as a result, the appearance of the main clinical symptoms of the disease.