The Role of Polymorphism of Hereditary Thrombophilia Candidate Genes in the Development of Arterial Hypertension in Women with Preeclampsia.

Abstract

Oleg V. Golovchenko, Maria Yu. Abramova, Oksana B. Altukhova, Irina N. Verzilina, Natalya A. Rudyh, Vladimir F. Kulikovsky

Preeclampsia is a severe pregnancy complication that has long been one of the leading causes of maternal and perinatal mortality and morbidity worldwide. Despite the achievements of modern medicine, the etiology of this pathology is not known. Multiple risk factors for the development of PE have been identified: arterial hypertension, diabetes mellitus, obesity, a hereditary history of preeclampsia, thrombophilia, etc., but recently, special attention has been paid to genetic determinants, namely, the contribution of individual polymorphic loci of various genes. In the course of our study, we studied the contribution of the rs5918 and rs1126643 polymorphisms of the GPIII and ITGA2 gene, respectively, associated with the development of hereditary thrombophilia, in the development of arterial hypertension, as one of the main symptoms of preeclampsia. The sample included 455 patients with PE; the average age of women was 26.41 ï ‚± 4.92 years. It was found that women with PE with CC genotype of rs5918 polymorphism of the GPIIIa gene had a more pronounced increase in blood pressure indicators (the distribution of CC, CT, and TT genotypes was 2.25% (n = 10), 25.68% (n = 114), 72.07% (n = 320)), and with the TT genotype of polymorphism rs1126643 of the ITGA2 gene, a more pronounced increase in SBP and DBP was observed (the frequency of TT, CT genotypes is 19.06% (n = 85), 48.43% (n = 216), 32.51% (n = 145) respectively). Thus, it was found that the CC rs5918 genotypes of the GPIII gene and TT rs1126643 of the ITGA2 gene are associated with a more pronounced increase in blood pressure in women with pre-eclampsia by the end of pregnancy. 41 ï ‚± 4.92 years. It was found that women with PE with CC genotype of rs5918 polymorphism of the GPIIIa gene had a more pronounced increase in blood pressure indicators (the distribution of CC, CT, and TT genotypes was 2.25% (n = 10), 25.68% (n = 114), 72.07% (n = 320)), and with the TT genotype of polymorphism rs1126643 of the ITGA2 gene, a more pronounced increase in SBP and DBP was observed (the frequency of TT, CT genotypes is 19.06% (n = 85), 48.43% (n = 216), 32.51% (n = 145) respectively). Thus, it was found that the CC rs5918 genotypes of the GPIII gene and TT rs1126643 of the ITGA2 gene are associated with a more pronounced increase in blood pressure in women with pre-eclampsia by the end of pregnancy. 41 ï ‚± 4.92 years. It was found that women with PE with CC genotype of rs5918 polymorphism of the GPIIIa gene had a more pronounced increase in blood pressure indicators (the distribution of CC, CT, and TT genotypes was 2.25% (n = 10), 25.68% (n = 114), 72.07% (n = 320)), and with the TT genotype of polymorphism rs1126643 of the ITGA2 gene, a more pronounced increase in SBP and DBP was observed (the frequency of TT, CT genotypes is 19.06% (n = 85), 48.43% (n = 216), 32.51% (n = 145) respectively). Thus, it was found that the CC rs5918 genotypes of the GPIII gene and TT rs1126643 of the ITGA2 gene are associated with a more pronounced increase in blood pressure in women with pre-eclampsia by the end of pregnancy. It was found that women with PE with CC genotype of rs5918 polymorphism of the GPIIIa gene had a more pronounced increase in blood pressure indicators (the distribution of CC, CT, and TT genotypes was 2.25% (n = 10), 25.68% (n = 114), 72.07% (n = 320)), and with the TT genotype of polymorphism rs1126643 of the ITGA2 gene, a more pronounced increase in SBP and DBP was observed (the frequency of TT, CT genotypes is 19.06% (n = 85), 48.43% (n = 216), 32.51% (n = 145) respectively). Thus, it was found that the CC rs5918 genotypes of the GPIII gene and TT rs1126643 of the ITGA2 gene are associated with a more pronounced increase in blood pressure in women with pre-eclampsia by the end of pregnancy. It was found that women with PE with CC genotype of rs5918 polymorphism of the GPIIIa gene had a more pronounced increase in blood pressure indicators (the distribution of CC, CT, and TT genotypes was 2.25% (n = 10), 25.68% (n = 114), 72.07% (n = 320)), and with the TT genotype of polymorphism rs1126643 of the ITGA2 gene, a more pronounced increase in SBP and DBP was observed (the frequency of TT, CT genotypes is 19.06% (n = 85), 48.43% (n = 216), 32.51% (n = 145) respectively). Thus, it was found that the CC rs5918 genotypes of the GPIII gene and TT rs1126643 of the ITGA2 gene are associated with a more pronounced increase in blood pressure in women with pre-eclampsia by the end of pregnancy. and with the TT genotype of polymorphism rs1126643 of the ITGA2 gene, a more pronounced increase in SBP and DBP was observed (the frequency of TT, CT genotypes is 19.06% (n = 85), 48.43% (n = 216), 32.51% (n = 145) respectively). Thus, it was found that the CC rs5918 genotypes of the GPIII gene and TT rs1126643 of the ITGA2 gene are associated with a more pronounced increase in blood pressure in women with pre-eclampsia by the end of pregnancy. and with the TT genotype of polymorphism rs1126643 of the ITGA2 gene, a more pronounced increase in SBP and DBP was observed (the frequency of TT, CT genotypes is 19.06% (n = 85), 48.43% (n = 216), 32.51% (n = 145) respectively). Thus, it was found that the CC rs5918 genotypes of the GPIII gene and TT rs1126643 of the ITGA2 gene are associated with a more pronounced increase in blood pressure in women with pre-eclampsia by the end of pregnancy.