The role of Trimetazidine in prevention of contrast induced nephropathy in diabetic patients with renal insufficiency undergoing cardiac intervention
Abstract
Ahmed N. Rajeeb, Khalid I. Amber, Najah R. Hadi, Hussein A. Alsalkhi, Bashaer M. Muhammad-Baqir, Mustafa H. Ahmed.
This study aims to assess the possible protective role of Trimetazidine in the prevention of contrast induced nephropathy in patients with renal impairment undergoing coronary angiography or percutaneous coronary intervention. This was a randomized single-blind clinical trial study. A total of 100 consecutive diabetic patients with symptomatic ischemic heart disease and chronic kidney disease (CKD) were subjected to an elective percutaneous coronary intervention, at ALSADR teaching hospital /Al-Najaf Center for Cardiac surgery and Tran Catheter Therapy, Najaf, Iraq, in period between May and December 2018. The Patients were divided into two groups: Group I-Control Group (n=45) these patients with chronic kidney disease and critical coronary stenosis and they were needed to be subjected to coronary intervention. Group II- Treatment Group (n=44) also these patients with chronic kidney disease and critical coronary stenosis and they were need to be subjected to coronary intervention and treated with 35 mg tablet /twice daily of Trimetazidine for the period of three days.
Trimetazidine significantly reduce the elevation in serum level of monocyte chemo tactic protein1, expression of Toll-like receptor 2 and the urine levels of kidney injury molecule-1,F2-isoprostanes (p<0.05) while insignificantly reduce the elevation in serum level of creatinine . (p > 0.05). Our study concluded that Trimetazidine reduce the acute kidney injury response and systemic inflammatory response induced by contrast administration after coronary intervention.
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| Pubmed Style Ahmed N. Rajeeb, Khalid I. Amber, Najah R. Hadi, Hussein A. Alsalkhi, Bashaer M. Muhammad-Baqir, Mustafa H. Ahmed. The role of Trimetazidine in prevention of contrast induced nephropathy in diabetic patients with renal insufficiency undergoing cardiac intervention. SRP. 2020; 11(1): 337-348. doi:10.5530/srp.2020.1.44 Web Style Ahmed N. Rajeeb, Khalid I. Amber, Najah R. Hadi, Hussein A. Alsalkhi, Bashaer M. Muhammad-Baqir, Mustafa H. Ahmed. The role of Trimetazidine in prevention of contrast induced nephropathy in diabetic patients with renal insufficiency undergoing cardiac intervention. http://www.sysrevpharm.org/?mno=84026 [Access: March 29, 2021]. doi:10.5530/srp.2020.1.44 AMA (American Medical Association) Style Ahmed N. Rajeeb, Khalid I. Amber, Najah R. Hadi, Hussein A. Alsalkhi, Bashaer M. Muhammad-Baqir, Mustafa H. Ahmed. The role of Trimetazidine in prevention of contrast induced nephropathy in diabetic patients with renal insufficiency undergoing cardiac intervention. SRP. 2020; 11(1): 337-348. doi:10.5530/srp.2020.1.44 Vancouver/ICMJE Style Ahmed N. Rajeeb, Khalid I. Amber, Najah R. Hadi, Hussein A. Alsalkhi, Bashaer M. Muhammad-Baqir, Mustafa H. Ahmed. The role of Trimetazidine in prevention of contrast induced nephropathy in diabetic patients with renal insufficiency undergoing cardiac intervention. SRP. (2020), [cited March 29, 2021]; 11(1): 337-348. doi:10.5530/srp.2020.1.44 Harvard Style Ahmed N. Rajeeb, Khalid I. Amber, Najah R. Hadi, Hussein A. Alsalkhi, Bashaer M. Muhammad-Baqir, Mustafa H. Ahmed (2020) The role of Trimetazidine in prevention of contrast induced nephropathy in diabetic patients with renal insufficiency undergoing cardiac intervention. SRP, 11 (1), 337-348. doi:10.5530/srp.2020.1.44 Turabian Style Ahmed N. Rajeeb, Khalid I. Amber, Najah R. Hadi, Hussein A. Alsalkhi, Bashaer M. Muhammad-Baqir, Mustafa H. Ahmed. 2020. The role of Trimetazidine in prevention of contrast induced nephropathy in diabetic patients with renal insufficiency undergoing cardiac intervention. Systematic Reviews in Pharmacy, 11 (1), 337-348. doi:10.5530/srp.2020.1.44 Chicago Style Ahmed N. Rajeeb, Khalid I. Amber, Najah R. Hadi, Hussein A. Alsalkhi, Bashaer M. Muhammad-Baqir, Mustafa H. Ahmed. "The role of Trimetazidine in prevention of contrast induced nephropathy in diabetic patients with renal insufficiency undergoing cardiac intervention." Systematic Reviews in Pharmacy 11 (2020), 337-348. doi:10.5530/srp.2020.1.44 MLA (The Modern Language Association) Style Ahmed N. Rajeeb, Khalid I. Amber, Najah R. Hadi, Hussein A. Alsalkhi, Bashaer M. Muhammad-Baqir, Mustafa H. Ahmed. "The role of Trimetazidine in prevention of contrast induced nephropathy in diabetic patients with renal insufficiency undergoing cardiac intervention." Systematic Reviews in Pharmacy 11.1 (2020), 337-348. Print. doi:10.5530/srp.2020.1.44 APA (American Psychological Association) Style Ahmed N. Rajeeb, Khalid I. Amber, Najah R. Hadi, Hussein A. Alsalkhi, Bashaer M. Muhammad-Baqir, Mustafa H. Ahmed (2020) The role of Trimetazidine in prevention of contrast induced nephropathy in diabetic patients with renal insufficiency undergoing cardiac intervention. Systematic Reviews in Pharmacy, 11 (1), 337-348. doi:10.5530/srp.2020.1.44 |
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