Thymoquinone Protect Against Hepatotoxicity and Nephrotoxicy Induced by Carbon Tetrachloride in Mice

Abstract

Nahidah Ibrahim Hammadi, Shaimaa Hajalan, Thana I Mustafa, Marwan Mahmood Saleh, Eman Naji Saleh.

Carbon tetrachloride (CcL4) is a toxic substance and has been the focal point of many toxic studies in vivo and in vitro. Thymoquinone (TQ), the lively ingredient of black seed oil, might also stop oxidative infection. Therefore, we took into account the practicable impact of TQ on protection in opposition to chemical agent poisoning and at the stage of lipid peroxide, and also possesses many residences inclusive of anti-inflammatory analgesic actions. In this study, 20 mice have been divided into four subgroups, every team consisting of 5 mice, according to the concentrations as follows:: The manage group(G1) with 5 mice (n=5) that used to be administered 0.1ml corn oil IP For 24h. Group 2 dealt with group/ mice given TQ(0.25ml) for 24h, Group 3 two contaminated group/ mice gived ccl4 (0.1 ml) for 24h and Group 4 defensive group/ mice gived earlier than 24h TQ (0.25ml) (IP) and after 24 h. gived ccl4 (0.l ml) for 24h. Histopathological examination of the liver and kidneys confirmed obvious damage in the group that administered Carbon tetrachloride. The defensive team showed a complete reflection of toxic outcomes in liver and kidney cells, This confirms that Thymoquinone used to be providing whole protection against poisonous substances.