To Consider The Organogel Of Span 40 And Span 60 In Sesame Oil As A New Member In The Gastro Retentive Drug Delivery Systems

Abstract

Zainab Saad Kaddoori, Masar Basim Mohsin Mohamed, Wesam R. Kadhum, Nawfal Am. Numan

To explore the ability of organogel for floating in acidic media to obtain a novel member gastroretentive dosage form testing span 40 and span 60 as a gelators, sesame oil (SO) as an apolar phase and cinnarizine (CN) as a model drug to produce an organogel as a gastroretentive drug delivery system. Floating properties were studied like floating lag time and floating duration for the organogels in both solid and liquid status. Characterizations of organogels were studied by assessment of thermal behavior by tabletop rheology and probing the organogels morphology with an optical microscope, the assembly of gelators was investigated by Fourier-transform infrared spectroscopy (FTIR). Oscillatory rheology studies, the amplitude sweep and frequency sweep were conducted. These were followed by in- vitro release and in-vivo floating studies. The results showed that all span organogels floated instantly and for around 24 hours in both statuses. Also, all span organogels showed reversible transition temperature and higher than 37 ºC and the optical images showed fibrillar scaffold where the fibers length of span 40 organogel were significantly shortening with increasing concentration of span 40 and the non significant change was with span 60.The hydrogen bonds were responsible on gelator-gelator interactions by a shift in the peaks that associated with the carbonyl and hydroxyl groups. Moreover, organogels showed the viscoelastic properties as the 20% w/w of span 40 and span 60 organogels were frequency independent. Last, organogels slowed the release of CN and persisted in rat’s stomach for 12 hours.

 

How to Cite this Article
Pubmed Style

Zainab Saad Kaddoori, Masar Basim Mohsin Mohamed, Wesam R. Kadhum, Nawfal Am. Numan. To Consider The Organogel Of Span 40 And Span 60 In Sesame Oil As A New Member In The Gastro Retentive Drug Delivery Systems. SRP. 2020; 11(5): 850-861. 
doi:10.31838/srp.2020.5.124

Web Style

Zainab Saad Kaddoori, Masar Basim Mohsin Mohamed, Wesam R. Kadhum, Nawfal Am. Numan. To Consider The Organogel Of Span 40 And Span 60 In Sesame Oil As A New Member In The Gastro Retentive Drug Delivery Systems. http://www.sysrevpharm.org/?mno=135742 [Access: March 30, 2021]. doi:10.31838/srp.2020.5.124

AMA (American Medical Association) Style

Zainab Saad Kaddoori, Masar Basim Mohsin Mohamed, Wesam R. Kadhum, Nawfal Am. Numan. To Consider The Organogel Of Span 40 And Span 60 In Sesame Oil As A New Member In The Gastro Retentive Drug Delivery Systems. SRP. 2020; 11(5): 850-861. doi:10.31838/srp.2020.5.124



Vancouver/ICMJE Style

Zainab Saad Kaddoori, Masar Basim Mohsin Mohamed, Wesam R. Kadhum, Nawfal Am. Numan. To Consider The Organogel Of Span 40 And Span 60 In Sesame Oil As A New Member In The Gastro Retentive Drug Delivery Systems. SRP. (2020), [cited March 30, 2021]; 11(5): 850-861. doi:10.31838/srp.2020.5.124



Harvard Style

Zainab Saad Kaddoori, Masar Basim Mohsin Mohamed, Wesam R. Kadhum, Nawfal Am. Numan (2020) To Consider The Organogel Of Span 40 And Span 60 In Sesame Oil As A New Member In The Gastro Retentive Drug Delivery Systems. SRP, 11 (5), 850-861. doi:10.31838/srp.2020.5.124



Turabian Style

Zainab Saad Kaddoori, Masar Basim Mohsin Mohamed, Wesam R. Kadhum, Nawfal Am. Numan. 2020. To Consider The Organogel Of Span 40 And Span 60 In Sesame Oil As A New Member In The Gastro Retentive Drug Delivery Systems. Systematic Reviews in Pharmacy, 11 (5), 850-861. doi:10.31838/srp.2020.5.124



Chicago Style

Zainab Saad Kaddoori, Masar Basim Mohsin Mohamed, Wesam R. Kadhum, Nawfal Am. Numan. "To Consider The Organogel Of Span 40 And Span 60 In Sesame Oil As A New Member In The Gastro Retentive Drug Delivery Systems." Systematic Reviews in Pharmacy 11 (2020), 850-861. doi:10.31838/srp.2020.5.124



MLA (The Modern Language Association) Style

Zainab Saad Kaddoori, Masar Basim Mohsin Mohamed, Wesam R. Kadhum, Nawfal Am. Numan. "To Consider The Organogel Of Span 40 And Span 60 In Sesame Oil As A New Member In The Gastro Retentive Drug Delivery Systems." Systematic Reviews in Pharmacy 11.5 (2020), 850-861. Print. doi:10.31838/srp.2020.5.124



APA (American Psychological Association) Style

Zainab Saad Kaddoori, Masar Basim Mohsin Mohamed, Wesam R. Kadhum, Nawfal Am. Numan (2020) To Consider The Organogel Of Span 40 And Span 60 In Sesame Oil As A New Member In The Gastro Retentive Drug Delivery Systems. Systematic Reviews in Pharmacy, 11 (5), 850-861. doi:10.31838/srp.2020.5.124

Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran SRP. 2020; 11(1): 14-22 » doi: 10.5530/srp.2019.1.3
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova SRP. 2019; 10(1): 112-117 » doi: 10.5530/srp.2019.1.19
Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review Karle Pravin P, Dhawale Shashikant C SRP. 2019; 10(1): 11-14 » doi: 0.5530/srp.2019.1.2
  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar SRP. 2019; 10(1): 20-25 » doi: 10.5530/srp.2019.1.4
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi SRP. 2019; 10(1): 15-19 » doi: 10.5530/srp.2019.1.3