Topical Indocyanine Green Nanosystem For Photodynamic Therapy of Cutaneous Warts
Nevien Samy, Maha Fadel, Doaa Abdelfadeel, Mohammed Al-Daraji
Background: Photodynamic therapy was proven very promising for the treatment of dermatological diseases, especially the resistant ones such as recalcitrant cutaneous warts.
Objective: to evaluate the efficacy and safety of photodynamic treatment of cutaneous warts using ICG carried in a Nano system drug carrier and prepared in a topical form (gel) as a photosensitizer in combination with diode laser as a source of radiation.
Methods: the efficiency of the nano-vesicular system (transethosomes) as a potential topical drug delivery system for the photosensitizer indocyanine green (ICG) was investigated followed by clinical photodynamic therapy (PDT) in patients suffering from cutaneous warts.
Results: Results revealed that ICG transethosomal gel displayed curative effects which were excellent in 19 cases, good in 9 cases and poor in 2 cases only. It also shows that recurrence was in only one case out of the total 30 cases with highly significant difference of dermatology life quality index DLQI before and after total treatment sessions and the mean of degree of improvement was (4.90 ± 1.09).
Conclusion: PDT using transethosomal ICG is an effective and safe therapeutic modality for the treatment of cutaneous warts.