Toxicity Test of Bioactive Red Alga Extract Eucheuma spinosum on Shrimp Artemia Salina Leach
Abstract
Nurlindah Hamrun, Teiza Nabilah, Rafikah Hasyim, Muhammad Ruslin, Irfan Dammar, Muhammad Anugrah As Arianto
Ameloblastoma is a benign epithelial neoplasm and ranges from 10% of all odontogenic tumors. Utilization of the bioactive compound red algae extract, which acts as an anti-carcinoma and improves the activity of abnormal cell metabolism, has the potential to suppress ameloblastoma recurrence. The Brine Shrimp Lethality Test (BSLT) method using Artemia salina Leach shrimp larvae as a test animal as an effort to search for novel anticancer compounds derived from plants. The purpose of this study was to find out the minimal dose of red algae extract of Eucheuma spinosum which has a toxic effect, the level of red algae toxicity of Eucheuma spinosum obtained in the variation of solvents, the number of mortality in the shrimp larvae of Artemia salina Leach after giving Eucheuma spinosum red extract, the potential of Eucheuma spinosum red algae extracts as an antitumor. Based on the result of this study, we obtained a straight line equation that showed a positive correlation. The concentration to kill 50% or LC50 larvae of Artemia salina Leach shrimp is 58.82 ppm that suggested the potential for toxicity in BSLT methods in experimental animals. Based on the study conducted, ethanol extract of red algae Eucheuma spinosum has the potential for toxic activity against shrimp larvae Artemia salina Leach by using the BSLT method with LC50 <1000 ppm. The LC50 values indicate that red algae Eucheuma spinosum extract has potential as an antitumor.
| How to Cite this Article |
| Pubmed Style Nurlindah Hamrun, Teiza Nabilah, Rafikah Hasyim, Muhammad Ruslin, Irfan Dammar, Muhammad Anugrah As Arianto. Toxicity Test of Bioactive Red Alga Extract Eucheuma spinosum on Shrimp Artemia Salina Leach . SRP. 2020; 11(5): 672-676. doi:10.31838/srp.2020.5.94 Web Style Nurlindah Hamrun, Teiza Nabilah, Rafikah Hasyim, Muhammad Ruslin, Irfan Dammar, Muhammad Anugrah As Arianto. Toxicity Test of Bioactive Red Alga Extract Eucheuma spinosum on Shrimp Artemia Salina Leach . http://www.sysrevpharm.org/?mno=114290 [Access: March 29, 2021]. doi:10.31838/srp.2020.5.94 AMA (American Medical Association) Style Nurlindah Hamrun, Teiza Nabilah, Rafikah Hasyim, Muhammad Ruslin, Irfan Dammar, Muhammad Anugrah As Arianto. Toxicity Test of Bioactive Red Alga Extract Eucheuma spinosum on Shrimp Artemia Salina Leach . SRP. 2020; 11(5): 672-676. doi:10.31838/srp.2020.5.94 Vancouver/ICMJE Style Nurlindah Hamrun, Teiza Nabilah, Rafikah Hasyim, Muhammad Ruslin, Irfan Dammar, Muhammad Anugrah As Arianto. Toxicity Test of Bioactive Red Alga Extract Eucheuma spinosum on Shrimp Artemia Salina Leach . SRP. (2020), [cited March 29, 2021]; 11(5): 672-676. doi:10.31838/srp.2020.5.94 Harvard Style Nurlindah Hamrun, Teiza Nabilah, Rafikah Hasyim, Muhammad Ruslin, Irfan Dammar, Muhammad Anugrah As Arianto (2020) Toxicity Test of Bioactive Red Alga Extract Eucheuma spinosum on Shrimp Artemia Salina Leach . SRP, 11 (5), 672-676. doi:10.31838/srp.2020.5.94 Turabian Style Nurlindah Hamrun, Teiza Nabilah, Rafikah Hasyim, Muhammad Ruslin, Irfan Dammar, Muhammad Anugrah As Arianto. 2020. Toxicity Test of Bioactive Red Alga Extract Eucheuma spinosum on Shrimp Artemia Salina Leach . Systematic Reviews in Pharmacy, 11 (5), 672-676. doi:10.31838/srp.2020.5.94 Chicago Style Nurlindah Hamrun, Teiza Nabilah, Rafikah Hasyim, Muhammad Ruslin, Irfan Dammar, Muhammad Anugrah As Arianto. "Toxicity Test of Bioactive Red Alga Extract Eucheuma spinosum on Shrimp Artemia Salina Leach ." Systematic Reviews in Pharmacy 11 (2020), 672-676. doi:10.31838/srp.2020.5.94 MLA (The Modern Language Association) Style Nurlindah Hamrun, Teiza Nabilah, Rafikah Hasyim, Muhammad Ruslin, Irfan Dammar, Muhammad Anugrah As Arianto. "Toxicity Test of Bioactive Red Alga Extract Eucheuma spinosum on Shrimp Artemia Salina Leach ." Systematic Reviews in Pharmacy 11.5 (2020), 672-676. Print. doi:10.31838/srp.2020.5.94 APA (American Psychological Association) Style Nurlindah Hamrun, Teiza Nabilah, Rafikah Hasyim, Muhammad Ruslin, Irfan Dammar, Muhammad Anugrah As Arianto (2020) Toxicity Test of Bioactive Red Alga Extract Eucheuma spinosum on Shrimp Artemia Salina Leach . Systematic Reviews in Pharmacy, 11 (5), 672-676. doi:10.31838/srp.2020.5.94 |
Abstract
PDF
How to cite this article
Related Records