Underdiagnosis Does not Account for the Decrease in Dengue Cases in Bandung, Indonesia
Abstract
Lia Faridah, Savira Ekawardhani, Hesti Lina Wiraswati, Nisa Fauziah, Fedri Ruluwedrata Rinawan, Wulan Mayasari, Kozo Watanabe
Introduction: Epidemics caused by outbreaks of the dengue virus (DENV) have been prevalent in Indonesia since it was first reported in 1968. Bandung, the capital city of West Java, Indonesia, is one of the regions where dengue is the most prevalent in Indonesia. Since late 2019; however, the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has become a worldwide public health challenge. Concurrently, a peculiar pattern of DENV incidence has emerged beginning in early 2020. Based on data from the West Java Provincial Health Office, a significant decrease in DENV cases occurred from January to July 2020 compared with that in 2019. One possible cause could be the underdiagnosis of dengue due to the overlap of clinical features with COVID-19.
Methodology: To test this hypothesis, we explored the possibility of under diagnosis or co-infection with COVID-19 and DENV by conducting multiplex real-time PCR of common arbovirus (DENV, Zika, Chikungunya) and SARS-Cov-2 on sera from patients with positive or negative COVID-19 swab test PCR results.
Results: Of the 284 sera tested, 41 were positive for SARS-Cov-2, and one serum was positive for both SARS-Cov-2 and DENV, whereas the rest were negative for arbovirus (DENV)
Conclusions: These results indicate that the co-infection of DENV and COVID-19 occurs only very rarely. We concluded that an underdiagnosis of DENV from January to July 2020 did not account for the significant decrease in cases in West Java, Indonesia.
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| Pubmed Style Faridah L, Ekawardhani S, Wiraswati HL, Fauziah N, Rinawan FR, Mayasari W, Watanabe K. Underdiagnosis Does not Account for the Decrease in Dengue Cases in Bandung, Indonesia. SRP. 2021; 12(1): 1340-1342. doi:10.31838/srp.2021.1.187 Web Style Faridah L, Ekawardhani S, Wiraswati HL, Fauziah N, Rinawan FR, Mayasari W, Watanabe K. Underdiagnosis Does not Account for the Decrease in Dengue Cases in Bandung, Indonesia. http://www.sysrevpharm.org/?mno=50034 [Access: March 31, 2021]. doi:10.31838/srp.2021.1.187 AMA (American Medical Association) Style Faridah L, Ekawardhani S, Wiraswati HL, Fauziah N, Rinawan FR, Mayasari W, Watanabe K. Underdiagnosis Does not Account for the Decrease in Dengue Cases in Bandung, Indonesia. SRP. 2021; 12(1): 1340-1342. doi:10.31838/srp.2021.1.187 Vancouver/ICMJE Style Faridah L, Ekawardhani S, Wiraswati HL, Fauziah N, Rinawan FR, Mayasari W, Watanabe K. Underdiagnosis Does not Account for the Decrease in Dengue Cases in Bandung, Indonesia. SRP. (2021), [cited March 31, 2021]; 12(1): 1340-1342. doi:10.31838/srp.2021.1.187 Harvard Style Faridah, L., Ekawardhani, . S., Wiraswati, . H. L., Fauziah, . N., Rinawan, . F. R., Mayasari, . W. & Watanabe, . K. (2021) Underdiagnosis Does not Account for the Decrease in Dengue Cases in Bandung, Indonesia. SRP, 12 (1), 1340-1342. doi:10.31838/srp.2021.1.187 Turabian Style Faridah, Lia, Savira Ekawardhani, Hesti Lina Wiraswati, Nisa Fauziah, Fedri Ruluwedrata Rinawan, Wulan Mayasari, and Kozo Watanabe. 2021. Underdiagnosis Does not Account for the Decrease in Dengue Cases in Bandung, Indonesia. Systematic Reviews in Pharmacy, 12 (1), 1340-1342. doi:10.31838/srp.2021.1.187 Chicago Style Faridah, Lia, Savira Ekawardhani, Hesti Lina Wiraswati, Nisa Fauziah, Fedri Ruluwedrata Rinawan, Wulan Mayasari, and Kozo Watanabe. "Underdiagnosis Does not Account for the Decrease in Dengue Cases in Bandung, Indonesia." Systematic Reviews in Pharmacy 12 (2021), 1340-1342. doi:10.31838/srp.2021.1.187 MLA (The Modern Language Association) Style Faridah, Lia, Savira Ekawardhani, Hesti Lina Wiraswati, Nisa Fauziah, Fedri Ruluwedrata Rinawan, Wulan Mayasari, and Kozo Watanabe. "Underdiagnosis Does not Account for the Decrease in Dengue Cases in Bandung, Indonesia." Systematic Reviews in Pharmacy 12.1 (2021), 1340-1342. Print. doi:10.31838/srp.2021.1.187 APA (American Psychological Association) Style Faridah, L., Ekawardhani, . S., Wiraswati, . H. L., Fauziah, . N., Rinawan, . F. R., Mayasari, . W. & Watanabe, . K. (2021) Underdiagnosis Does not Account for the Decrease in Dengue Cases in Bandung, Indonesia. Systematic Reviews in Pharmacy, 12 (1), 1340-1342. doi:10.31838/srp.2021.1.187 |
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