VEGETABLE-BASED TRITERPENOID MILIACIN LIMITS INSULIN RESISTANCE IN RATS IN EXPERIMENT

Abstract

S. I. KRASIKOV, N. V. SHARAPOVA, D.S. KARMANOVA.

Vistar rats received the vegetable-based triterpenoid 3-b-methoxy-D18-oleanene in the amount of 0.2 mg per kg of body weight simultaneously with a high-calorie diet. At the end of the 4-week experiment, in the group of rats receiving miliacin in combination with a high-calorie diet, serum glucose and insulin levels did not differ significantly from those of the control group and the group of rats receiving miliacin. At the same time, the concentration of glucose and insulin in the animals of this group was, on average, 30% lower than in the group of rats fed a high-calorie diet. Comparisons of HOMA-IR (Homeostasis Model Assessment of Insulin Resistance) for the groups "high-calorie diet" and "high-calorie diet and miliacin" showed that the consumption of miliacin in combination with a high-calorie diet led to a significant decrease in the insulin resistance index by 2 times. The use of miliacin for the prevention of IR seems promising from the point of view of its effectiveness shown by the absence of a toxic effect in an experiment on animals. The results of the study broaden the understanding of biological effects range of miliacin as a promising agent for insulin resistance decrement.