A Deevan Paul

Department of Pharmaceutical Sciences, Chettinad Academy of Research and Education, Chennai, India


  • Research Article   
    Application of Statistical Tools-Mixture Optimal Designs on Optimization of Glipizide Controlled Release Tablets
    Author(s): Kunisetti Nagendra Babu37926* and A Deevan Paul37927

    The principal aim of this paper is to apply the experimental design of experiments (mixture designs) to formulate a solid dosage form (glipizide controlled release tablets) using push pull osmotic drug delivery systems through the study of the excipients and their proportion in the formulation. The effect of different formulation variable namely, amount of Poly ethylene oxide in push and pull layers, amount of sodium chloride in push layer and effect of percentage weight gain of semi permeable membrane which influence the dissolution on 4 hrs, 8 hrs and 16 hrs was analysed. The design space obtained range between 156.943 mg-160.246 mg of Poly ethylene oxide (3 Lakh Molecular Weight (MW)), 84.5853 mg-84.8986 mg of Poly ethylene oxide (70 Lakh Molecular Weight) and 30.169 mg-32.1584 mg of Sodium chloride. All factors having significant effect on dissolution... Read More»
    DOI: 10.31858/0975-8453.13.3.188-195

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