Hrvoje Mazija
Department of Biomedical Sciences, MEDEX D.O.O. Company, Ljubljana, SloveniaPublications
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Research Article
Determining of the Human Interferon-Alfa and its Natural Subtypes' Pro- or Anti-Inflammatory, Antiproliferative and Cytocidal Activity In Vitro
Author(s): Bratko Filipič40808*, Sandor Toth40809, Lidija Gradišnik40810, Adriana Pereyra40811 and Hrvoje Mazija40812
As a type I Interferon’s, Human leukocyte Interferonalfa (HuIFN-αN3) is a complex pleiotropic molecule composed from several natural subtypes, showing: Antiviral, proor anti-inflammatory and antiproliferative activity in vitro. The present work was aimed to detect, analyze and compare the natural subtype’s composition of HuIFN-αN3 from EGIS (Budapest, Hungary) or IMZ (Zagreb, Croatia) and to measure theirs proor anti-inflammatory, antiproliferative and cytocidal activity in vitro. HuIFN-αN3 from EGIS, (Budapest, Hungary) or IMZ, (Zagreb, Croatia) contains seven “minor” (a-g) and eight “major” (1-8) subtypes with the isoelectric points: 8.12, 7.40, 7.02, 6.90, 6.45, 6.06, 4.45, and 5.80, 5.65, 5.50, 5.30, 5.05, 4.88, 4.72, 4.53. Subtypes show different pro and anti-inflammatory effects. Those separated in the range.. Read More»
DOI: 10.31858/0975-8453.13.8.531-538