Mais Fadhel Mohammed

Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq


  • Research Article   
    Comparison In-vitro Release and pH Effect among Different Oral Antidiabetic Drugs: A Review
    Author(s): Omar S Salih42725*, Mowafaq M Ghareeb42726 and Mais Fadhel Mohammed42727

    Diabetes is a metabolic condition that affects how the body utilizes digested food for growth and energy. The majority of the food we consume is broken down into glucose, which is the form of sugar in our blood. Glucose is the body’s primary fuel source. The solubility of glibenclamide (glibenclamide), metformin, and sitagliptin was evaluated in triplicate in different pH using a water bath shaker at 37°C using the shake- flask technique. The quantity of medicine accessible for absorption is determined by the drug release. Each drug’s physiochemical characteristics have a substantial impact on release along the G.I.T. For each medication, calibration curve and solubility measurements were performed. In the duodenum and the small intestine, glibenclamide was released more efficiently and fast than metformin and sitagliptin, which had higher pKa values than gl.. Read More»
    DOI: 10.31858/0975-8453.13.6.366-370

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