Muditha B Herath

Department of Chemistry, College of Chemical Sciences, Institute of Chemistry Ceylon, Rajagiriya, Sri Lanka


  • Research Article   
    Development, Validation, and Concentration Determination of Losartan Potassium Using 1D UV Visible Spectrophotometry
    Author(s): Maneesha C Abeysekera35048, Muditha B Herath35049, Shehani H Basnagoda35050 and Udaya K Jayasundara35051*

    Losartan Potassium (LP) is a non-peptide antihypertensive agent that manifests its effect by specifically blocking angiotensin II receptors which are used to treat hypertension. This research was carried out to develop and validate a simple and accurate Ultraviolet- Visible (UV-Vis) spectrometric method to determine the Active Pharmaceutical Ingredient (API) content in commercially available LP formulations stored at room temperature and refrigerator conditions. All the parameters were validated following the International Conference on Harmonization (ICH) guidelines. An intense peak at 234 nm was observed for the first derivative 1D UV spectrum of LP and it was taken for the quantitative evaluation. Accuracy was tested with the spiked recovery method and the percentage recovery was observed in the range of 90% to 110%. Precision was evaluated utilizing intra-day and inter-day precisi.. Read More»
    DOI: 10.31858/0975-8453.13.2.116-121

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