Neelaveni Padayachee
Department of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South AfricaPublications
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Research Article
Dolutegravir Reported Adverse Drug Reactions: A Systematic Review Protocol
Author(s): Lesley Wadesango42471*, Ebenezer Wiafe42472, Kofi Boamah Mensah42473, Varsha Bangalee42474 and Neelaveni Padayachee42475
Background: Until recently, the first-line regimen for the management of Human Immunodeficiency Virus (HIV) was Tenofovir (TDF)-Emtricitabine (FTC) and Efavirenz (EFV). However, the use of EFV has now been limited due to adverse neurosensory effects and a low genetic barrier to resistance. This regimen has been replaced by the Dolutegravir (DTG)-based regimen since DTG has a high genetic barrier to resistance. Studies have reported a higher risk of Immune Reconstitution Inflammatory Syndrome (IRIS), weight gain, insomnia, and neural tube defects amongst people who received DTG. This review aims to assess the Adverse Drug Reaction (ADR) profile of Dolutegravir by identifying and classifying Dolutegravir-associated adverse drug reactions. Methods: Studies will be identified from an electronic database search. Studies that are potentially eligi.. Read More»
DOI: 10.31858/0975-8453.13.9.635-638