Shinya Goto
Department of Cardiovascular Surgery, Mori Clinic, Tokyo, JapanPublications
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Research Article
Sub-acute Effects of Vaccination With a Messenger RNA-based Vaccine against Coronavirus Disease 2019 on Elderly Japanese Patients with Cardiac Disorder
Author(s): Ryuichi Tamimoto41138, Toshiharu Fujii41139, Hirofumi Nagamatsu41140, Tsutomu Murakami41141, Koji Miyazaki41142, Shinya Goto41143, Yasunori Cho41144 and Hidezo Mori41145*
Background: The incidence of acute myocarditis as a sub-acute side effect after vaccination with an mRNA- based vaccine against Coronavirus Disease 2019 (COVID-19) in elderly patients with cardiac dysfunction is unknown. This study assessed adverse cardiac events following vaccination. Methods: This observational study evaluated all- cause mortality and deterioration of heart failure in 100 Japanese patients who underwent vaccination with an mRNA-based vaccine against COVID-19. Heart failure status was assessed using the Brain Natriuretic Peptide (BNP) ratio, for which the BNP or N Terminal (NT)-pro BNP values were divided by their Upper Normal Limits (UNL). Deterioration was assessed based on changes in the BNP ratio; values (i.e., post-BNP levels minus pre-BNP levels) ≥ 10-fold higher than the UNL denoted significant increment. .. Read More»
DOI: 10.31858/0975-8453.13.8.552-556