A Brief Review on CAR-T Cell Therapy

Abstract

Bodi Gayathri28455*, Sariki Ashok Krishnan28456 and Korimelli Sridevi28458

Cancer is one of the significant causes of death around the world. Chimeric Antigen Receptor-T cell therapy is the immunotherapeutic treatment for cancer involving collection of T cells from patient’s blood and is genetically modified in-vitro to express Chimeric Antigen Receptor. These modified T cells are reinfused into patient where they can recognize the tumor specific antigen resulting anti-tumor activity. This cytotoxic effect can also result in toxic effects like Cytokine Release Syndrome, neurotoxicity and off-tumor toxicity which can be fatal. Further research and development are required to improve the anti-cancer efficacy. This review describes about the structure of Chimeric Antigen Receptor, production of Chimeric Antigen Receptor-T cells, major adverse effects and their management.