Abstract

Delgermaa Tsagaankhuu64610, Chimeglkham Banzrai64611, Tsagaankhuu Guntev64612* and Baigalmaa Gongor64613

Objective: The present study aimed to compare the safety and efficacy of Intravenous Thrombolysis (IVT) between Mongolian young and older patients with Acute Ischemic Stroke (AIS).

Methods: Data of 115 AIS patients who received recombinant tissue Plasminogen Activator (rt-PA) between May 2013 and May 2023 at the Stroke Center of Third Central Hospital were retrospectively analyzed. Patients aged <50 years (n=31) compared with those aged ≥ 50 years (n=84) with regards to baseline characteristics, symptomatic Intracerebral Haemorrhage (sICH), functional outcomes at 3 months defined as “favorable” and “poor” (modified Rankin Scale score 0-2 vs. 3-6) including in-hospital mortality.

Results: 27% of patients were <50 years old (54.8% males; mean age 42.7 ± 5.8 years). Ischemic heart disease was significantly less common in younger patients than older (22.6% vs. 58.3%, p=0.018) and

the prevalence of other determined ethiology was higher (p<0.05) in patients aged <50 years. “Favorable” outcome at 3 months was significantly higher in young adults (61.3% vs.36.9%, p=0.033) and sICH was found in 3.3% of the patients aged <50 years (p=0.897) compared to 6.0% in the older than 50 years. Mortality was present in 9.7% of the patients aged <50 years and in 21.4% of the patients aged ≥ 50 years (p=0.182). Conclusion: We conclude that Mongolian young stroke patients treated with IVT had a more favorable outcome without an increased risk of sICH and mortality compared with older patients.