Edible Mushroom Significantly Ameliorated Hepatorenal Toxicity of Butyl Paraben (BP) in Albino Rats

Abstract

Kassahun Berhane38662*, Reza Darvishi38663 and Saeed Bahwerth38664

Introduction: Parabens are used commonly as preservatives in a range of cosmetics applied to the under arm and breast area as well as popular preservatives because of their cost.

Aim of the work: This study was done to evaluate the neprohepatic toxicity of parabens.

Materials and methods: Thirty adult female rats were used and given paraben orally for six months at parabens at dose of 10% of the LD50 (Median Lethal Dose) equal to 4.6 mg/kg/bw. Mushroom was given orally to at dose of 10 mg/kg/day for six months too.

Results: Oral administration of BP induced biochemical and histopathological changes. Biochemical changes: BP toxicity manifested by changes in the liver and kidney function tests manifested by increase AST, ALT, Bilirubin, urea and creatinine with decreases to plasma proteins in comparison to control group. Giving mushroom caused amelioration to the nephrohepatic toxicity by inducing recovery in liver and kidney functions in comparison to paraben treated group. For histopathological findings: BP induced vascular congestion in liver and kidney in association with necrotic changes in the hepatorenal epithelium which improved after mushroom treatment.

Conclusion: BP induced hepatorenal toxicity which improved by mushroom treatment.

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