Reza Darvishi

Department of Molecular Biology, Molecular Biology Research Center, Khorramabad, Iran


  • Research Article   
    Edible Mushroom Significantly Ameliorated Hepatorenal Toxicity of Butyl Paraben (BP) in Albino Rats
    Author(s): Kassahun Berhane38662*, Reza Darvishi38663 and Saeed Bahwerth38664

    Introduction: Parabens are used commonly as preservatives in a range of cosmetics applied to the under arm and breast area as well as popular preservatives because of their cost. Aim of the work: This study was done to evaluate the neprohepatic toxicity of parabens. Materials and methods: Thirty adult female rats were used and given paraben orally for six months at parabens at dose of 10% of the LD50 (Median Lethal Dose) equal to 4.6 mg/kg/bw. Mushroom was given orally to at dose of 10 mg/kg/day for six months too. Results: Oral administration of BP induced biochemical and histopathological changes. Biochemical changes: BP toxicity manifested by changes in the liver and kidney function tests manifested by increase AST, ALT, Bilirubin, urea and creatinine with decreases to plasma proteins .. Read More»
    DOI: 10.31858/0975-8453.13.6.371-376

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